Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.58 |
| ▸ | F2R | P25116 | 3/20 | 0.43 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.42 |
| ▸ | QPCT | Q16769 | 1/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | CETP | P11597 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.40 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.38 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7337887 | 0.94 | DRD4 (0.55) | DRD4F2RSIGMAR1QPCTOPRM1 | |
| SCHEMBL7342120 | 0.89 | DRD4 (0.45) | DRD4SIGMAR1OPRM1CHRM2CHRM1 | |
| SCHEMBL7348192 | 0.89 | DRD4 (0.47) | DRD4SIGMAR1CYP1A2CYP2D6 | |
| SCHEMBL7344285 | 0.87 | CYP2D6 (0.47) | DRD4OPRM1CYP1A2CYP2D6 | |
| SCHEMBL7339633 | 0.84 | CYP1A2 (0.46) | DRD4OPRM1CYP1A2CYP2D6 | |
| SCHEMBL7344567 | 0.83 | CYP1A2 (0.47) | DRD4SIGMAR1CYP1A2CYP2D6 | |
| SCHEMBL7343396 | 0.82 | CYP1A2 (0.45) | DRD4OPRM1CYP1A2CYP2D6 | |
| SCHEMBL7344115 | 0.82 | CYP1A2 (0.45) | DRD4OPRM1CYP1A2CYP2D6 | |
| SCHEMBL7337002 | 0.82 | CYP1A2 (0.45) | DRD4OPRM1CYP1A2CYP2D6 | |
| SCHEMBL7342001 | 0.80 | CYP1A2 (0.41) | CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0598962-B1 | Imidazole derivatives as calcium channel blockers | NEUROSEARCH AS (DK) | 1999-02-17 | — | — | EP | claimed |
| EP-0598962-A1 | Imidazole derivatives as calcium channel blockers | NEUROSEARCH A/S (DK) | 1994-06-01 | — | — | EP | disclosed |
| US-5296493-A | Analgesics or antiischemics | NEUROSEARCH A/S (DK) | 1994-03-22 | — | — | US | disclosed |