Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
| ▸ | CNR2 | P34972 | 3/20 | 0.41 |
| ▸ | CNR1 | P21554 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342120 | 0.96 | DRD4 (0.45) | DRD4CNR2CNR1CYP2D6CYP1A2 | |
| SCHEMBL7344285 | 0.90 | CYP2D6 (0.47) | DRD4CYP2D6CYP1A2CYP2C19TSHR | |
| SCHEMBL7339647 | 0.89 | DRD4 (0.58) | DRD4CYP2D6CYP1A2SIGMAR1 | |
| SCHEMBL7337887 | 0.89 | DRD4 (0.55) | DRD4CYP2D6CYP1A2SIGMAR1 | |
| SCHEMBL7339933 | 0.87 | CYP1A2 (0.42) | DRD4CNR2CNR1CYP2D6CYP1A2 | |
| SCHEMBL7339633 | 0.86 | CYP1A2 (0.46) | DRD4CYP2D6CYP1A2CYP2C19TSHR | |
| SCHEMBL7337002 | 0.85 | CYP1A2 (0.45) | DRD4CNR2CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL7344115 | 0.85 | CYP1A2 (0.45) | DRD4CNR2CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL7343396 | 0.85 | CYP1A2 (0.45) | DRD4CNR2CYP2D6CYP1A2CYP2C19 | |
| SCHEMBL7341171 | 0.84 | NR1H2 (0.47) | CYP2D6CYP1A2CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0598962-B1 | Imidazole derivatives as calcium channel blockers | NEUROSEARCH AS (DK) | 1999-02-17 | — | — | EP | claimed |
| EP-0598962-A1 | Imidazole derivatives as calcium channel blockers | NEUROSEARCH A/S (DK) | 1994-06-01 | — | — | EP | disclosed |
| US-5296493-A | Analgesics or antiischemics | NEUROSEARCH A/S (DK) | 1994-03-22 | — | — | US | disclosed |