Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSS | P25774 | 8/20 | 0.59 |
| ▸ | PSMB11 | A5LHX3 | 2/20 | 0.53 |
| ▸ | PSMA7 | O14818 | 2/20 | 0.53 |
| ▸ | PSMB1 | P20618 | 2/20 | 0.53 |
| ▸ | PSMA1 | P25786 | 2/20 | 0.53 |
| ▸ | PSMA2 | P25787 | 2/20 | 0.53 |
| ▸ | PSMA3 | P25788 | 2/20 | 0.53 |
| ▸ | PSMA4 | P25789 | 2/20 | 0.53 |
| ▸ | PSMB8 | P28062 | 2/20 | 0.53 |
| ▸ | PSMB9 | P28065 | 2/20 | 0.53 |
| ▸ | PSMA5 | P28066 | 2/20 | 0.53 |
| ▸ | PSMB4 | P28070 | 2/20 | 0.53 |
| ▸ | PSMB6 | P28072 | 2/20 | 0.53 |
| ▸ | PSMB5 | P28074 | 2/20 | 0.53 |
| ▸ | PSMB10 | P40306 | 2/20 | 0.53 |
| ▸ | PSMB3 | P49720 | 2/20 | 0.53 |
| ▸ | PSMB2 | P49721 | 2/20 | 0.53 |
| ▸ | PSMA6 | P60900 | 2/20 | 0.53 |
| ▸ | PSMA8 | Q8TAA3 | 2/20 | 0.53 |
| ▸ | PSMB7 | Q99436 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21023244 | 0.92 | CACNA1B (0.58) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL11938562 | 0.92 | CACNA1B (0.58) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL7344929 | 0.92 | CACNA1B (0.58) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL7342873 | 0.92 | CACNA1B (0.58) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL7344934 | 0.92 | CACNA1B (0.58) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL7345113 | 0.92 | CACNA1B (0.58) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL7342880 | 0.92 | CACNA1B (0.58) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL7345107 | 0.92 | CACNA1B (0.58) | PSMB11PSMA7PSMB1PSMA1PSMA2 | |
| SCHEMBL7346714 | 0.91 | POLB (0.58) | CTSSPSMB11PSMA7PSMB1PSMA1 | |
| SCHEMBL7346720 | 0.91 | POLB (0.58) | CTSSPSMB11PSMA7PSMB1PSMA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975623-B1 | INDAZOLE AMIDE COMPOUNDS AS SEROTONINERGIC AGENTS | ACRAF (IT) | 2002-06-19 | — | — | EP | claimed |
| US-6197769-B1 | SEROTONINE RECEPTORS ANTAGONIST; GASTROINTESTINAL DISORDERS, ANTIARRHYTHMIA AGENTS; INCONTINENCE | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2001-03-06 | — | — | US | claimed |
| EP-0975623-A2 | INDAZOLE AMIDE COMPOUNDS AS SEROTONINERGIC AGENTS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) | 2000-02-02 | — | — | EP | claimed |
| WO-1998046589-A2 | INDAZOLE AMIDE COMPOUNDS AS SEROTONINERGIC AGENTS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 1998-10-22 | — | — | WO | claimed |
| US-9403791-B1 | Coumarin derivatives for cancer therapy | WELLESLEY COLLEGE (US) | 2016-08-02 | — | — | US | disclosed |
| US-9388155-B1 | Coumarin derivatives for cancer therapy | WELLESLEY COLLEGE (US) | 2016-07-12 | — | — | US | disclosed |
| EP-0975623-B1 | INDAZOLE AMIDE COMPOUNDS AS SEROTONINERGIC AGENTS | ACRAF (IT) | 2002-06-19 | — | — | EP | disclosed |
| US-6197769-B1 | SEROTONINE RECEPTORS ANTAGONIST; GASTROINTESTINAL DISORDERS, ANTIARRHYTHMIA AGENTS; INCONTINENCE | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2001-03-06 | — | — | US | disclosed |
| EP-0975623-A2 | INDAZOLE AMIDE COMPOUNDS AS SEROTONINERGIC AGENTS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.p.A. (IT) | 2000-02-02 | — | — | EP | disclosed |
| WO-1998046589-A2 | INDAZOLE AMIDE COMPOUNDS AS SEROTONINERGIC AGENTS | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 1998-10-22 | — | — | WO | disclosed |