Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 4/20 | 0.47 |
| ▸ | MMP9 | P14780 | 1/20 | 0.46 |
| ▸ | MMP8 | P22894 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
| ▸ | REN | P00797 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | CPA1 | P15085 | 1/20 | 0.44 |
| ▸ | ACE2 | Q9BYF1 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 2/20 | 0.43 |
| ▸ | CTSK | P43235 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | CTSL | P07711 | 1/20 | 0.42 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7341933 | 0.95 | PPARG (0.50) | PPARGMMP9MMP8PLGPRSS1 | |
| SCHEMBL7346201 | 0.92 | PPARG (0.48) | PPARGMMP9MMP8PLGPRSS1 | |
| SCHEMBL7341957 | 0.91 | PLG (0.50) | PPARGMMP9MMP8PLGPRSS1 | |
| SCHEMBL7345736 | 0.90 | REN (0.51) | PPARGMMP9MMP8PLGPRSS1 | |
| SCHEMBL7346535 | 0.88 | PPARG (0.44) | PPARGMMP9MMP8PLGPRSS1 | |
| SCHEMBL7337025 | 0.88 | KLKB1 (0.52) | PPARGMMP9MMP8MMEACE | |
| SCHEMBL7337451 | 0.87 | PPARG (0.48) | PPARGMMP9MMP8PLGPRSS1 | |
| SCHEMBL7338155 | 0.87 | PPARG (0.48) | PPARGMMP9MMP8PLGPRSS1 | |
| SCHEMBL7340612 | 0.86 | PPARG (0.47) | PPARGMMP9MMP8PLGPRSS1 | |
| SCHEMBL7342765 | 0.86 | PLG (0.61) | PLGPRSS1PRSS2PRSS3REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6423689-B1 | Peptidyl calcium channel blockers | WARNER-LAMBERT COMPANY | 2002-07-23 | — | — | US | claimed |
| US-6423689-B1 | Peptidyl calcium channel blockers | WARNER-LAMBERT COMPANY | 2002-07-23 | — | — | US | disclosed |