Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 10/20 | 0.38 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.38 |
| ▸ | PDE2A | O00408 | 3/20 | 0.38 |
| ▸ | PDE4A | P27815 | 3/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.37 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.37 |
| ▸ | IDO1 | P14902 | 1/20 | 0.37 |
| ▸ | PDE1A | P54750 | 1/20 | 0.35 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.35 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.35 |
| ▸ | ADH5 | P11766 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7342065 | 0.85 | PDE3B (0.40) | PDE3BPDE3APDE2APDE4APDE4B | |
| SCHEMBL7345593 | 0.83 | GRIK1 (0.47) | — | |
| SCHEMBL7342584 | 0.81 | PDE3B (0.49) | PDE3BPDE3APDE2APDE4APDE4B | |
| Hydrochloric Acid SCHEMBL7348587 | 0.80 | PDE3B (0.48) | PDE3BPDE3APDE2APDE4APDE4B | |
| SCHEMBL7349137 | 0.80 | PDE4B (0.39) | PDE3BPDE3APDE2APDE4APDE4B | |
| SCHEMBL10517424 | 0.76 | PDE3B (0.42) | PDE3BPDE3APDE2APDE4APDE4B | |
| SCHEMBL7350884 | 0.75 | PDE3B (0.45) | PDE3BPDE3APDE2APDE4APDE4B | |
| SCHEMBL997561 | 0.69 | IDO1 (0.53) | IDO1LMNACYP1A2CYP3A4CYP2D6 | |
| SCHEMBL7344749 | 0.68 | GRIK1 (0.49) | — | |
| SCHEMBL7342548 | 0.67 | PDE3B (0.38) | PDE3BPDE3APDE2APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0329691-B1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-11-21 | — | — | EP | disclosed |
| EP-0329691-A1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES. | SCHERING AG (DE) | 1989-08-30 | — | — | EP | disclosed |
| WO-1988003531-A1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-05-19 | — | — | WO | disclosed |
| US-4737511-A | Cardiotonic imidazolylphenylpyrrol-2-ones | SCHERING A.G. (DE) | 1988-04-12 | — | — | US | disclosed |