Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIK1 | P39086 | 1/20 | 0.47 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.47 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.47 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.47 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.47 |
| ▸ | GRIK2 | Q13002 | 1/20 | 0.47 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.47 |
| ▸ | GRIK4 | Q16099 | 1/20 | 0.47 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7344749 | 0.86 | GRIK1 (0.49) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7340723 | 0.83 | PDE3B (0.38) | — | |
| SCHEMBL7342402 | 0.82 | KDM4E (0.52) | — | |
| SCHEMBL7342584 | 0.78 | PDE3B (0.49) | — | |
| Hydrochloric Acid SCHEMBL7348587 | 0.77 | PDE3B (0.48) | — | |
| SCHEMBL7345017 | 0.77 | LMNA (0.44) | — | |
| SCHEMBL10066486 | 0.75 | GRIK1 (0.52) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL995544 | 0.73 | GRIK1 (0.56) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL10786918 | 0.70 | GRIK1 (0.57) | GRIK1GRIA1GRIA2GRIA3GRIA4 | |
| SCHEMBL7350046 | 0.69 | ALDH1A1 (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0329691-B1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1991-11-21 | — | — | EP | disclosed |
| EP-0329691-A1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES. | SCHERING AG (DE) | 1989-08-30 | — | — | EP | disclosed |
| WO-1988003531-A1 | CARDIOTONIC IMIDAZOLYLPHENYLPYRROL-2-ONES | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-05-19 | — | — | WO | disclosed |
| US-4737511-A | Cardiotonic imidazolylphenylpyrrol-2-ones | SCHERING A.G. (DE) | 1988-04-12 | — | — | US | disclosed |