Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 9/20 | 0.67 |
| ▸ | PLG | P00747 | 4/20 | 0.64 |
| ▸ | NPC1 | O15118 | 5/20 | 0.57 |
| ▸ | RAB9A | P51151 | 4/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.57 |
| ▸ | TP53 | P04637 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 2/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.51 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.50 |
| ▸ | PLAT | P00750 | 4/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343249 | 0.87 | STAT3 (0.54) | PLAUPLGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7341753 | 0.84 | MEN1 (0.53) | PLAUPLGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7340171 | 0.82 | RAB9A (0.44) | PLAUPLGNPC1RAB9AMEN1 | |
| SCHEMBL7336457 | 0.82 | NPC1 (0.53) | PLAUPLGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7341946 | 0.81 | PLAU (0.67) | PLAUPLGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7340329 | 0.81 | PLAU (0.63) | PLAUPLGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7337311 | 0.81 | PLAU (0.58) | PLAUPLGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7337325 | 0.81 | PLAU (0.58) | PLAUPLGNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7335937 | 0.80 | DEGS1 (0.57) | NPC1RAB9AMEN1KMT2ACASP3 | |
| SCHEMBL7341723 | 0.80 | NPC1 (0.48) | PLAUPLGNPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6284796-B1 | NAPHTHAMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-09-04 | — | — | US | claimed |
| US-6284796-B1 | NAPHTHAMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-09-04 | — | — | US | disclosed |