Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 17/20 | 0.84 |
| ▸ | PDE4A | P27815 | 11/20 | 0.84 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.84 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.84 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | PDE5A | O76074 | 2/20 | 0.50 |
| ▸ | PDE1A | P54750 | 1/20 | 0.50 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.50 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7336538 | 1.00 | PDE4D (0.84) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7336534 | 1.00 | PDE4D (0.84) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7335660 | 0.95 | PDE4D (0.79) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7338639 | 0.95 | PDE4D (0.79) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7338627 | 0.95 | PDE4D (0.79) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7335658 | 0.95 | PDE4D (0.79) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| Piclamilast SCHEMBL26573 | 0.92 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7335911 | 0.91 | PDE4D (0.98) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL7354173 | 0.89 | PDE4D (0.83) | PDE4DPDE4APDE4BPDE4CCYP2B6 | |
| SCHEMBL70770 | 0.87 | PDE4D (0.80) | PDE4DPDE4APDE4BPDE4CCYP2B6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1996031476-A1 | AROMATIC HYDROXYETHERS | RHONE-POULENC RORER LIMITED (GB) | 1996-10-10 | — | — | WO | disclosed |