⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Butyrolactone SCHEMBL13728757 | 0.77 | CA1 (0.64) | — | |
| SCHEMBL371880 | 0.76 | — | — | |
| SCHEMBL971354 | 0.76 | — | — | |
| SCHEMBL156559 | 0.76 | — | — | |
| SCHEMBL1302083 | 0.76 | — | — | |
| SCHEMBL17094565 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL9734775 | 0.74 | — | — | |
| SCHEMBL151065 | 0.72 | CA1 (0.70) | — | |
| SCHEMBL17866212 | 0.72 | CA1 (0.70) | — | |
| SCHEMBL23853654 | 0.71 | CA1 (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 64 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7723325-B2 | 5-amido-indole-2-carboxamide derivatives | HOFFMAN-LA ROCHE INC. (US) | 2010-05-25 | — | — | US | claimed |
| US-20090264418-A1 | 5-AMIDO-INDOLE-2-CARBOXAMIDE DERIVATIVES | NETTEKOVEN MATTHIAS | 2009-10-22 | — | — | US | claimed |
| US-7601711-B2 | Such as [5-(4-cyclopentyl-piperazine-1-carbonyl)-1H-indol-2-yl]-morpholin-4-yl-methanone; histamine H3-antagonists | HOFFMANN-LA ROCHE INC. (US) | 2009-10-13 | — | — | US | claimed |
| EP-2010487-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. Hoffmann-Roche AG (CH) | 2009-01-07 | — | — | EP | claimed |
| WO-2007115938-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | claimed |
| US-20070244125-A1 | 5-amido-indole-2-carboxamide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | US | claimed |
| US-12215199-B2 | Polypropylene backbone, and nanoporous polypropylene membrane | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2025-02-04 | — | — | US | disclosed |
| US-20240376090-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERED RELATED THERETO | ARENA PHARMACEUTICALS, INC. (US) | 2024-11-14 | — | — | US | disclosed |
| US-20240279241-A1 | PYRIDO[4,3-D]PYRIMIDINE COMPOUNDS CAPABLE OF INHIBITING KRAS MUTANT PROTEINS | REDX PHARMA PLC (GB) | 2024-08-22 | — | — | US | disclosed |
| EP-4247875-A1 | FUNCTIONALIZED POLYGLYCINE-POLY(ALKYLENIMINE) COPOLYMERS, THEIR PREPARATION AND USE FOR PREPARING ACTIVE INGREDIENT FORMULATIONS AND SPECIAL-EFFECT SUBSTANCE FORMULATIONS | Friedrich-Schiller-Universität Jena (DE) | 2023-09-27 | — | — | EP | disclosed |
| EP-4247874-A1 | FUNCTIONALISED POLYGLYCINE-POLY(ALKYLENE IMINE)-COPOLYMERS, THE PREPARATION THEREOF AND USE THEREOF FOR PREPARING FORMULATIONS OF OR FOR COMPLEXING ANIONIC ACTIVE INGREDIENTS AND EFFECT SUBSTANCES | Friedrich-Schiller-Universität Jena (DE) | 2023-09-27 | — | — | EP | disclosed |
| EP-4236942-A1 | ISOXAZOLE DERIVATIVES AS MODULATORS OF THE 5-HT2A SEROTONIN RECEPTOR USEFUL FOR THE TREATMENT OF DISORDERS RELATED THERETO | Arena Pharmaceuticals, Inc. (US) | 2023-09-06 | — | — | EP | disclosed |
| US-20220169802-A1 | FILM FROM GRAFT COPOLYMER HAVING A POLYPROPYLENE BACKBONE, AND NANOPOROUS POLYPROPYLENE MEMBRANE | SABIC GLOBAL TECHNOLOGIES B.V. (NL) | 2022-06-02 | — | — | US | disclosed |
| US-20080220048-A1 | implantable medical equipment coated with biocompatible polymers based on modified [1,4]oxazepan-7-one, used as in situ time-release agents or drug delivery devices; prevention of restenosis, aneurysms and plaque | MEDTRONIC VASCULAR, INC. (US) | 2008-09-11 | — | — | US | disclosed |
| US-20080220048-A1 | implantable medical equipment coated with biocompatible polymers based on modified [1,4]oxazepan-7-one, used as in situ time-release agents or drug delivery devices; prevention of restenosis, aneurysms and plaque | MEDTRONIC VASCULAR, INC. (US) | 2008-09-11 | — | — | US | disclosed |
| WO-2007115938-A1 | 5-AMIDO-2-CARBOXAMIDE INDOLES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | WO | disclosed |
| US-20070244125-A1 | 5-amido-indole-2-carboxamide derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-18 | — | — | US | disclosed |
| WO-2007024481-A2 | 4-AZA-CAPROLACTONE-BASED POLYMERIC COMPOSITIONS USEFUL FOR THE MANUFACTURE OF BIODEGRADABLE MEDICAL DEVICES AND AS MEDICAL DEVICE COATINGS | MEDTRONIC VASCULAR, INC. (US) | 2007-03-01 | — | — | WO | disclosed |
| WO-2007024481-A2 | 4-AZA-CAPROLACTONE-BASED POLYMERIC COMPOSITIONS USEFUL FOR THE MANUFACTURE OF BIODEGRADABLE MEDICAL DEVICES AND AS MEDICAL DEVICE COATINGS | MEDTRONIC VASCULAR, INC. (US) | 2007-03-01 | — | — | WO | disclosed |
| WO-2007024501-A2 | NITRIC OXIDE-RELEASING BIODEGRADABLE POLYMERS USEFUL AS MEDICAL DEVICES AND COATINGS THEREFORE | MEDTRONIC VASCULAR, INC. (US) | 2007-03-01 | — | — | WO | disclosed |