Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.54 |
| ▸ | F12 | P00748 | 9/20 | 0.54 |
| ▸ | F2 | P00734 | 6/20 | 0.54 |
| ▸ | F10 | P00742 | 5/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.54 |
| ▸ | PLG | P00747 | 4/20 | 0.54 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | C1R | P00736 | 2/20 | 0.54 |
| ▸ | KLK1 | P06870 | 2/20 | 0.54 |
| ▸ | HGFAC | Q04756 | 2/20 | 0.54 |
| ▸ | TMPRSS2 | O15393 | 1/20 | 0.54 |
| ▸ | MLNR | O43193 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.54 |
| ▸ | HPN | P05981 | 1/20 | 0.54 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.54 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.54 |
| ▸ | C1S | P09871 | 1/20 | 0.54 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL10918389 | 1.00 | PLAU (0.54) | PLAUF12F2F10PRSS1 | |
| SCHEMBL7341983 | 0.98 | F12 (0.56) | PLAUF12F2F10PRSS1 | |
| Acetic Acid SCHEMBL7340710 | 0.97 | PLAU (0.53) | PLAUF12F2F10PRSS1 | |
| SCHEMBL10918392 | 0.89 | PLAU (0.49) | PLAUF12F2F10PRSS1 | |
| SCHEMBL7348791 | 0.85 | F12 (0.64) | PLAUF12F2F10PRSS1 | |
| SCHEMBL7337750 | 0.82 | F12 (0.71) | PLAUF12F2F10PRSS1 | |
| SCHEMBL7342919 | 0.82 | KMT2A (0.64) | PLAUF12F2F10PRSS1 | |
| SCHEMBL7347942 | 0.80 | FTO (0.70) | PLAUF12F2F10PRSS1 | |
| SCHEMBL10922456 | 0.78 | FTO (0.74) | PLAUF12F2F10PRSS1 | |
| SCHEMBL31380450 | 0.78 | F12 (0.76) | PLAUF12F2F10PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4454338-A | 6-AMIDINO-2-NATHTHYL-4-GUANIDINOBENZOATE | TORII & CO., LTD. (JP) | 1984-06-12 | — | — | US | disclosed |