Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.44 |
| ▸ | CRHBP | P24387 | 1/20 | 0.44 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6968035 | 0.95 | SMN1; SMN2 (0.48) | SMN1; SMN2TP53HTTALDH1A1TDP1 | |
| SCHEMBL20558473 | 0.89 | TP53 (0.52) | SMN1; SMN2TP53HTTALDH1A1TDP1 | |
| SCHEMBL29529192 | 0.89 | ALDH1A1 (0.51) | SMN1; SMN2TP53HTTALDH1A1TDP1 | |
| SCHEMBL2616867 | 0.89 | ALDH1A1 (0.51) | SMN1; SMN2TP53HTTALDH1A1TDP1 | |
| SCHEMBL19695886 | 0.88 | SMN1; SMN2 (0.49) | SMN1; SMN2TP53HTTALDH1A1TDP1 | |
| SCHEMBL17742882 | 0.85 | ALDH1A1 (0.54) | SMN1; SMN2ALDH1A1TDP1CYP3A4MAPT | |
| SCHEMBL9080764 | 0.83 | TP53 (0.49) | SMN1; SMN2TP53HTTALDH1A1TDP1 | |
| SCHEMBL3340975 | 0.82 | NPSR1 (0.52) | SMN1; SMN2ALDH1A1TDP1MAPTMAPK1 | |
| SCHEMBL1625485 | 0.82 | ALDH1A1 (0.51) | SMN1; SMN2ALDH1A1TDP1CYP3A4MAPT | |
| SCHEMBL4095909 | 0.81 | ALDH1A1 (0.58) | SMN1; SMN2TP53HTTALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3562806-A1 | METHODS FOR THE PREPARATION OF 6-AMINOISOQUINOLINE | Aerie Pharmaceuticals, Inc. (US) | 2019-11-06 | — | — | EP | claimed |
| WO-2018125548-A1 | METHODS FOR THE PREPARATION OF 6-AMINOISOQUINOLINE | AERIE PHARMACEUTICALS, INC. (US) | 2018-07-05 | — | — | WO | claimed |
| US-9840468-B1 | Methods for the preparation of 6-aminoisoquinoline | AERIE PHARMACEUTICALS, INC. (US) | 2017-12-12 | — | — | US | claimed |
| EP-3562806-A1 | METHODS FOR THE PREPARATION OF 6-AMINOISOQUINOLINE | Aerie Pharmaceuticals, Inc. (US) | 2019-11-06 | — | — | EP | disclosed |
| WO-2018125548-A1 | METHODS FOR THE PREPARATION OF 6-AMINOISOQUINOLINE | AERIE PHARMACEUTICALS, INC. (US) | 2018-07-05 | — | — | WO | disclosed |
| WO-2018125548-A1 | METHODS FOR THE PREPARATION OF 6-AMINOISOQUINOLINE | AERIE PHARMACEUTICALS, INC. (US) | 2018-07-05 | — | — | WO | disclosed |
| US-9840468-B1 | Methods for the preparation of 6-aminoisoquinoline | AERIE PHARMACEUTICALS, INC. (US) | 2017-12-12 | — | — | US | disclosed |
| US-9840468-B1 | Methods for the preparation of 6-aminoisoquinoline | AERIE PHARMACEUTICALS, INC. (US) | 2017-12-12 | — | — | US | disclosed |
| US-9840468-B1 | Methods for the preparation of 6-aminoisoquinoline | AERIE PHARMACEUTICALS, INC. (US) | 2017-12-12 | — | — | US | disclosed |
| US-6284796-B1 | NAPHTHAMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-09-04 | — | — | US | disclosed |