Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 13/20 | 0.80 |
| ▸ | PDE4A | P27815 | 10/20 | 0.80 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.80 |
| ▸ | PDE4C | Q08493 | 10/20 | 0.80 |
| ▸ | PDE5A | O76074 | 4/20 | 0.71 |
| ▸ | PDE1A | P54750 | 2/20 | 0.71 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.71 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.71 |
| ▸ | NPC1 | O15118 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | RAB9A | P51151 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8197050 | 0.91 | PDE4D (0.82) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7340175 | 0.89 | PDE4D (1.00) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7332928 | 0.87 | PDE4D (0.79) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7334095 | 0.85 | PDE4D (0.72) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7363154 | 0.85 | PDE4D (0.61) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7910791 | 0.84 | ALDH1A1 (0.68) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7335842 | 0.83 | PDE5A (1.00) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7334025 | 0.83 | PDE4D (0.82) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7423277 | 0.82 | PDE4D (0.78) | PDE4DPDE4APDE4BPDE4CPDE5A | |
| SCHEMBL7334681 | 0.82 | PDE5A (0.78) | PDE4DPDE4APDE4BPDE4CPDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 18 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5935978-A | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group | RHONE-POULENC RORER LIMITED (GB) | 1999-08-10 | — | — | US | claimed |
| EP-0497564-B1 | Benzamides | RHONE POULENC RORER LTD (GB) | 1995-12-27 | — | — | EP | claimed |
| US-6255326-B1 | ANTIINFLAMMATORY AGENT; AUTOIMMUNE DISEASES | AVENTIS PHARMA LIMITED (GB) | 2001-07-03 | — | — | US | disclosed |
| US-6096768-A | ADMINISTERING A 3, 5, 6-SUBSTITUTED PHENYL COMPOUND FOR THE TREATMENT OF INFLAMMATION AND AUTOIMMUNE DISORDERS | RHONE-POULENC RORER LIMITED (GB) | 2000-08-01 | — | — | US | disclosed |
| US-5935978-A | Compounds containing phenyl linked to aryl or heteroaryl by an aliphatic- or heteroatom-containing linking group | RHONE-POULENC RORER LIMITED (GB) | 1999-08-10 | — | — | US | disclosed |
| US-5840724-A | COMPOUNDS FOR TUMOR NECROSIS FACTOR OR ENZYME INHIBITORS OF PHOSPHODIESTERASES | RHONE-POULENC RORER LIMITED (GB) | 1998-11-24 | — | — | US | disclosed |
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |
| US-5698711-A | INHIBITORS OF TUMOR NECROSIS FACTOR, CYCLIC ADENOSINE-3*,5*-MONOPHOSPHATE PHOSPHODIESTERASE AND EOSINOPHILS | RHONE-POULENC RORER LIMITED (GB) | 1997-12-16 | — | — | US | disclosed |
| US-5679696-A | FOR INHIBITING TUMOR NECROSIS FACTOR; ENZYME INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1997-10-21 | — | — | US | disclosed |
| EP-0741707-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1996-11-13 | — | — | EP | disclosed |
| EP-0497564-B1 | Benzamides | RHONE POULENC RORER LTD (GB) | 1995-12-27 | — | — | EP | disclosed |
| EP-0669311-A1 | Benzamides | RHONE POULENC RORER LIMITED (GB) | 1995-08-30 | — | — | EP | disclosed |
| WO-1995020578-A1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE-POULENC RORER LIMITED (GB) | 1995-08-03 | — | — | WO | disclosed |
| EP-0652868-A1 | INHIBITORS OF c-AMP PHOSPHODIESTERASE AND TNF | RHONE-POULENC RORER LIMITED (GB) | 1995-05-17 | — | — | EP | disclosed |
| WO-1994002465-A1 | INHIBITORS OF c-AMP PHOSPHODIESTERASE AND TNF | RHONE-POULENC RORER LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |
| EP-0569414-A1 | BENZAMIDES | RHONE-POULENC RORER LIMITED (GB) | 1993-11-18 | — | — | EP | disclosed |
| WO-1992012961-A1 | BENZAMIDES | RHONE POULENC RORER LIMITED (GB) | 1992-08-06 | — | — | WO | disclosed |
| EP-0497564-A1 | Benzamides | RHONE POULENC RORER LIMITED (GB) | 1992-08-05 | — | — | EP | disclosed |