Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 18/20 | 0.61 |
| ▸ | PLG | P00747 | 8/20 | 0.50 |
| ▸ | KLK1 | P06870 | 8/20 | 0.50 |
| ▸ | PLAT | P00750 | 6/20 | 0.50 |
| ▸ | F2 | P00734 | 6/20 | 0.50 |
| ▸ | PRSS1 | P07477 | 5/20 | 0.50 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL7342930 | 1.00 | PLAU (0.61) | PLAUPLGKLK1PLATF2 | |
| SCHEMBL7343484 | 0.90 | PLAU (0.70) | PLAUPLGKLK1PLATF2 | |
| Trifluoroacetic Acid SCHEMBL7856857 | 0.86 | PLAU (0.83) | PLAUPLGKLK1PLATF2 | |
| Trifluoroacetic Acid SCHEMBL7336904 | 0.83 | PLAU (0.59) | PLAUPLGKLK1PLATF2 | |
| Trifluoroacetic Acid SCHEMBL7339090 | 0.80 | PLAU (0.57) | PLAUPLGKLK1PLATF2 | |
| SCHEMBL7343131 | 0.78 | KMT2A (0.48) | PLAUPLGKLK1PLATF2 | |
| Trifluoroacetic Acid SCHEMBL7337301 | 0.78 | PLAU (0.64) | PLAUPLGKLK1PLATF2 | |
| SCHEMBL7343324 | 0.78 | PLAU (0.50) | PLAUPLGKLK1PLATF2 | |
| Trifluoroacetic Acid SCHEMBL7335260 | 0.77 | PLAU (0.53) | PLAUPLGKLK1PLATF2 | |
| SCHEMBL7338672 | 0.77 | PLAU (1.00) | PLAUPLGKLK1PLATF2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819125-A1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1998-01-21 | — | — | EP | claimed |
| WO-1996031492-A1 | THIENYL-, FURYL-, PYRROLYL- AND BIPHENYLSULFONAMIDES AND DERIVATIVES THEREOF THAT MODULATE THE ACTIVITY OF ENDOTHELIN | TEXAS BIOTECHNOLOGY CORPORATION (US) | 1996-10-10 | — | — | WO | claimed |
| US-20010049374-A1 | Urokinase inhibitors | STEELE ANDREW W (US) | 2001-12-06 | — | — | US | disclosed |
| US-6284796-B1 | NAPHTHAMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-09-04 | — | — | US | disclosed |
| US-6258822-B1 | ENZYME INHIBITORS OF NAPHTHALENE AMIDINE COMPOUNDS | ABBOTT LABORATORIES | 2001-07-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20010049374-A1 | Urokinase inhibitors | SERPINE1, PLAU, SERPINB1 | PLAU 2/4885PLG 10/4885KLK1 62/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.