Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | FABP7 | O15540 | 1/20 | 0.43 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.43 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10778853 | 1.00 | POLB (0.46) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7378922 | 0.90 | SMN1; SMN2 (0.49) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL6222025 | 0.90 | SMN1; SMN2 (0.49) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7378920 | 0.90 | SMN1; SMN2 (0.49) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL10571017 | 0.88 | FABP7 (0.50) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7394116 | 0.87 | POLB (0.47) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL14762670 | 0.86 | POLB (0.45) | POLBPSEN1PSEN2APH1BNCSTN | |
| SCHEMBL7022852 | 0.85 | POLB (0.49) | POLBSMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL7022855 | 0.85 | POLB (0.49) | POLBSMN1; SMN2NPC1RAB9AHTR2C | |
| SCHEMBL11281703 | 0.82 | NPC1 (0.45) | POLBPSEN1PSEN2APH1BNCSTN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4316906-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-02-23 | — | — | US | disclosed |