Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | FABP7 | O15540 | 1/20 | 0.48 |
| ▸ | FABP5 | Q01469 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.46 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.46 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.46 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.46 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.46 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.46 |
| ▸ | AGTR2 | P50052 | 2/20 | 0.46 |
| ▸ | ACE | P12821 | 2/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6222025 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9AFABP7FABP5 | |
| SCHEMBL7378920 | 1.00 | SMN1; SMN2 (0.49) | SMN1; SMN2NPC1RAB9AFABP7FABP5 | |
| SCHEMBL6218940 | 0.92 | NPC1 (0.45) | SMN1; SMN2NPC1RAB9AFABP7FABP5 | |
| SCHEMBL11268603 | 0.92 | NPC1 (0.45) | SMN1; SMN2NPC1RAB9AFABP7FABP5 | |
| SCHEMBL11281703 | 0.92 | NPC1 (0.45) | SMN1; SMN2NPC1RAB9AFABP7FABP5 | |
| SCHEMBL6220282 | 0.91 | POLB (0.48) | SMN1; SMN2NPC1RAB9APOLBAGTR2 | |
| SCHEMBL10571017 | 0.91 | FABP7 (0.50) | SMN1; SMN2NPC1RAB9AFABP7FABP5 | |
| SCHEMBL6218057 | 0.90 | POLB (0.45) | SMN1; SMN2NPC1RAB9APOLBAGTR2 | |
| SCHEMBL11248084 | 0.90 | KDM1A (0.44) | SMN1; SMN2NPC1RAB9APOLBPSEN1 | |
| SCHEMBL7343530 | 0.90 | POLB (0.46) | SMN1; SMN2NPC1RAB9AFABP7FABP5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0053902-B1 | PHOSPHINYLALKANOYL SUBSTITUTED PROLINES | E.R. Squibb & Sons, Inc. (US) | 1985-04-03 | — | — | EP | disclosed |
| US-4384123-A | Phosphinylalkanoyl substituted prolines | E. R. SQUIBB & SONS, INC. (US) | 1983-05-17 | — | — | US | disclosed |
| US-4337201-A | Phosphinylalkanoyl substituted prolines | E. R. SQUIBB & SONS, INC. (US) | 1982-06-29 | — | — | US | disclosed |
| EP-0053902-A1 | Phosphinylalkanoyl substituted prolines | E.R. Squibb & Sons, Inc. (US) | 1982-06-16 | — | — | EP | disclosed |