Known targets — ChEMBL curated mechanism
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
The experimentally established mechanism targets of Sulfuric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.35 |
| ▸ | ADRA1A known ✓ | P35348 | 1/20 | 0.35 |
| ▸ | ADRA1B known ✓ | P35368 | 1/20 | 0.35 |
| ▸ | AVPR2 | P30518 | 5/20 | 0.41 |
| ▸ | AVPR1A | P37288 | 5/20 | 0.41 |
| ▸ | AVPR1B | P47901 | 4/20 | 0.41 |
| ▸ | CCR8 | P51685 | 2/20 | 0.38 |
| ▸ | BRPF1 | P55201 | 2/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7336265 | 0.97 | AVPR2 (0.42) | AVPR2AVPR1AAVPR1BCCR8BRPF1 | |
| Hydrochloric Acid SCHEMBL7345642 | 0.97 | AVPR2 (0.42) | AVPR2AVPR1AAVPR1BCCR8BRPF1 | |
| Hydrochloric Acid SCHEMBL7773784 | 0.97 | AVPR2 (0.42) | AVPR2AVPR1AAVPR1BCCR8BRPF1 | |
| SCHEMBL7336166 | 0.96 | AVPR2 (0.42) | AVPR2AVPR1AAVPR1BCCR8BRPF1 | |
| Hydrochloric Acid SCHEMBL7335182 | 0.95 | AVPR2 (0.42) | AVPR2AVPR1AAVPR1BCCR8BRPF1 | |
| SCHEMBL7340231 | 0.95 | AVPR2 (0.45) | AVPR2AVPR1AAVPR1BBRPF1BRD4 | |
| Hydrochloric Acid SCHEMBL7348666 | 0.94 | AVPR2 (0.44) | AVPR2AVPR1AAVPR1BBRPF1BRD4 | |
| Cadaverine Tartrate SCHEMBL7347950 | 0.93 | AVPR2 (0.41) | AVPR2AVPR1AAVPR1BBRPF1BRD4 | |
| SCHEMBL7338927 | 0.93 | AVPR2 (0.39) | AVPR2AVPR1AAVPR1BMEN1KMT2A | |
| SCHEMBL7346393 | 0.92 | AVPR2 (0.39) | AVPR2AVPR1AAVPR1BMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832061-B1 | BENZAMIDE DERIVATIVES AND THEIR USE AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO (JP) | 2001-09-05 | — | — | EP | disclosed |
| US-6054457-A | Benzamide derivatives and their use as vasopressin antagonists | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 2000-04-25 | — | — | US | disclosed |
| EP-0832061-A1 | BENZAMIDE DERIVATIVES AND THEIR USE AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996041795-A1 | BENZAMIDE DERIVATIVES AND THEIR USE AS VASOPRESSIN ANTAGONISTS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-12-27 | — | — | WO | disclosed |