Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.44 |
| ▸ | HTR1B | P28222 | 1/20 | 0.44 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.40 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.40 |
| ▸ | PDE6A | P16499 | 1/20 | 0.40 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.40 |
| ▸ | MC4R | P32245 | 1/20 | 0.40 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7338142 | 0.91 | HTR1D (0.48) | HTR1DHTR1BCYP2C19CYP1A2CYP2D6 | |
| SCHEMBL7346849 | 0.86 | NR1H2 (0.47) | HTR1DHTR1BSIGMAR1CYP2C19CYP1A2 | |
| SCHEMBL7339933 | 0.84 | CYP1A2 (0.42) | GRIA2SIGMAR1CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL7338944 | 0.83 | CYP2C19 (0.45) | GRIA2SIGMAR1CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL7337729 | 0.79 | TSHR (0.50) | HTR1DHTR1BCYP2C19CYP1A2CYP2D6 | |
| SCHEMBL7336987 | 0.78 | CNR2 (0.38) | GRIA2CYP1A2CYP2D6CNR1CNR2 | |
| SCHEMBL7339207 | 0.76 | CYP2D6 (0.49) | HTR1DHTR1BCYP2C19CYP1A2CYP2D6 | |
| SCHEMBL7345751 | 0.75 | CYP2D6 (0.47) | HTR1DHTR1BCYP2C19CYP1A2CYP2D6 | |
| SCHEMBL7338899 | 0.75 | TSHR (0.44) | HTR1DHTR1BCYP2C19CYP1A2CYP2D6 | |
| SCHEMBL7344285 | 0.74 | CYP2D6 (0.47) | CYP2C19CYP1A2CYP2D6KMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0598962-B1 | Imidazole derivatives as calcium channel blockers | NEUROSEARCH AS (DK) | 1999-02-17 | — | — | EP | claimed |
| EP-0598962-A1 | Imidazole derivatives as calcium channel blockers | NEUROSEARCH A/S (DK) | 1994-06-01 | — | — | EP | disclosed |
| US-5296493-A | Analgesics or antiischemics | NEUROSEARCH A/S (DK) | 1994-03-22 | — | — | US | disclosed |