Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MAOA | P21397 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | NQO1 | P15559 | 1/20 | 0.45 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.45 |
| ▸ | RELA | Q04206 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7344315 | 1.00 | TSHR (0.54) | TSHRNPC1RAB9AKMT2AMAOA | |
| SCHEMBL27029050 | 0.86 | TSHR (0.47) | TSHRKMT2AMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL27029056 | 0.86 | TSHR (0.47) | TSHRKMT2AMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL27029087 | 0.86 | TSHR (0.47) | TSHRKMT2AMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL27133236 | 0.86 | TSHR (0.47) | TSHRKMT2AMAPK1SMN1; SMN2L3MBTL1 | |
| SCHEMBL29097148 | 0.83 | TSHR (0.45) | TSHRMAPTALDH1A1PLA2G4BSMN1; SMN2 | |
| SCHEMBL7144597 | 0.83 | EDNRA (0.54) | TSHRNPC1RAB9AKMT2AMAOA | |
| SCHEMBL7293698 | 0.83 | EDNRA (0.54) | TSHRNPC1RAB9AKMT2AMAOA | |
| SCHEMBL9258771 | 0.83 | EDNRA (0.54) | TSHRNPC1RAB9AKMT2AMAOA | |
| SCHEMBL6229779 | 0.83 | EDNRA (0.54) | TSHRNPC1RAB9AKMT2AMAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4808580-A | Naphtho[1,2-b][1,4]thiazepin-4(5H)-ones and use thereof in treatment of ischemia and blood pressure lowering | HOFFMANN-LA ROCHE INC. (US) | 1989-02-28 | — | — | US | disclosed |
| EP-0239050-A1 | 2,3-Dihydro-2-phenyl-5-aminoalkyl-naphto ¬1,8-bc -1,5-thiazocin-4 (5H)-one derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1987-09-30 | — | — | EP | disclosed |
| EP-0234561-A2 | 2,3-Dihydro-2-phenyl-5-aminoalkyl-naphtho [1,2-b]-1,4-thiazepin-4(5H)-one derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1987-09-02 | — | — | EP | disclosed |
| US-4652561-A | HYPOTENSIVE AGENTS, ANTIISCHEMIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1987-03-24 | — | — | US | disclosed |
| US-4640930-A | CALCIUM CHANNEL BLOCKERS | HOFFMANN-LA ROCHE INC. (US) | 1987-02-03 | — | — | US | disclosed |