Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 3/20 | 0.54 |
| ▸ | EDNRB | P24530 | 2/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CES2 | O00748 | 2/20 | 0.47 |
| ▸ | CES1 | P23141 | 2/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7144597 | 1.00 | EDNRA (0.54) | EDNRAEDNRBTSHRCES2CES1 | |
| SCHEMBL6228156 | 1.00 | EDNRA (0.54) | EDNRAEDNRBTSHRCES2CES1 | |
| SCHEMBL9258771 | 1.00 | EDNRA (0.54) | EDNRAEDNRBTSHRCES2CES1 | |
| SCHEMBL7293698 | 1.00 | EDNRA (0.54) | EDNRAEDNRBTSHRCES2CES1 | |
| SCHEMBL8927247 | 0.98 | EDNRA (0.53) | EDNRAEDNRBTSHRCES2CES1 | |
| SCHEMBL7410333 | 0.84 | ELANE (0.50) | TSHREPHX1SMN1; SMN2MEN1TP53 | |
| SCHEMBL8503544 | 0.84 | BACE1 (0.52) | EDNRAEDNRBTSHRCES2CES1 | |
| SCHEMBL8856846 | 0.84 | BACE1 (0.52) | EDNRAEDNRBTSHRCES2CES1 | |
| SCHEMBL7141149 | 0.84 | BACE1 (0.52) | EDNRAEDNRBTSHRCES2CES1 | |
| SCHEMBL8577007 | 0.84 | PARP10 (0.48) | EDNRAEDNRBTSHRCES2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 89 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2780177-B1 | METHOD FOR PRODUCING POLYDIENES AND POLYDIENE COPOLYMERS WITH REDUCED COLD FLOW | BRIDGESTONE CORP (JP) | 2016-03-23 | — | — | EP | claimed |
| EP-0498706-B2 | Process for the preparation of (-)-(2R,3S)-2,3-epoxy-3-(4-methoxyphenyl)methylpropionate | SYNTHELABO (FR) | 2000-05-31 | — | — | EP | claimed |
| EP-0453330-B2 | Process for the preparation of (-) (2R,3S)-2,3-epoxy-3-(4-methoxyphenyl) propionic acid methylester and its enantiomer | SYNTHELABO (FR) | 1997-12-03 | — | — | EP | claimed |
| EP-0609031-B1 | Process for preparing benzothiazepine derivatives | SHIONOGI & CO (JP) | 1997-08-13 | — | — | EP | claimed |
| EP-0498706-A1 | Process for the preparation of (-)-(2R,3S)-2,3-epoxy-3-(4-methoxyphenyl)methylpropionate | SYNTHELABO (FR) | 1992-08-12 | — | — | EP | claimed |
| EP-0453330-A1 | Process for the preparation of (-) (2R,3S)-2,3-epoxy-3-(4-methoxyphenyl) propionic acid methylester and its enantiomer | SYNTHELABO (FR) | 1991-10-23 | — | — | EP | claimed |
| US-4885375-A | Resolution of 3-(4-methoxyphenyl)glycidic acid with in situ conversion to alkyl esters | MARION LABORATORIES, INC. (US) | 1989-12-05 | — | — | US | claimed |
| EP-0342902-A2 | 2-Hydroxy-propanoic acid acyclic alkyl esters for benzothiazepines | MARION LABORATORIES, INC. (a Delaware corporation) (US) | 1989-11-23 | — | — | EP | claimed |
| JP-61145173-A | — | — | None | — | — | JP | disclosed |
| JP-9255673-A | — | — | None | — | — | JP | disclosed |
| JP-9255672-A | — | — | None | — | — | JP | disclosed |
| JP-2231480-A | — | — | None | — | — | JP | disclosed |
| JP-58194872-A | — | — | None | — | — | JP | disclosed |
| JP-6298751-A | — | — | None | — | — | JP | disclosed |
| EP-0156734-A2 | Triazolo[4,3-b]pyridazines, process for their preparation and pharmaceutical compositions containing them | SANOFI S.A. (FR) | 1985-10-02 | — | — | EP | disclosed |
| EP-0154838-A1 | Novel 1,5-benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions | Tanabe Seiyaku Co., Ltd. (JP) | 1985-09-18 | — | — | EP | disclosed |
| EP-0127882-A1 | Novel 8-chloro-1,5-benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions | Tanabe Seiyaku Co., Ltd. (JP) | 1984-12-12 | — | — | EP | disclosed |
| US-4420628-A | Process for preparing threo-2-hydroxy-3-(4-methoxyphenyl)-3-(2-nitrophenylthio)-propionic ester | TANABE SEIYAKU CO., LTD. (JP) | 1983-12-13 | — | — | US | disclosed |
| JP-S58194872-A | PREPARATION OF BENZOTHIAZEPINE DERIVATIVE | TOKAWA TETSUO | 1983-11-12 | — | — | JP | disclosed |
| JP-H00678790-A | — | — | 0001-01-01 | — | — | JP | disclosed |