Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 6/20 | 0.64 |
| ▸ | HTT | P42858 | 4/20 | 0.64 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.52 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 2/20 | 0.49 |
| ▸ | MAOA | P21397 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9205238 | 0.85 | NPC1 (0.68) | MAPK1HTTNPSR1GAAMAPT | |
| SCHEMBL11264402 | 0.84 | MAPK1 (0.85) | MAPK1HTTNPSR1GAATDP1 | |
| SCHEMBL7226899 | 0.82 | MAPK1 (0.58) | MAPK1HTTNPSR1GAATDP1 | |
| SCHEMBL4689851 | 0.81 | MAPK1 (0.67) | MAPK1HTTNPSR1GAATDP1 | |
| SCHEMBL4992909 | 0.81 | MAPT (0.69) | MAPK1HTTNPSR1GAAMAPT | |
| SCHEMBL7227194 | 0.80 | MAPK1 (0.56) | MAPK1HTTNPSR1GAATDP1 | |
| SCHEMBL7344338 | 0.79 | MAPK1 (0.55) | MAPK1HTTNPSR1GAATDP1 | |
| SCHEMBL7233139 | 0.79 | HTT (0.55) | MAPK1HTTNPSR1GAATDP1 | |
| SCHEMBL7233144 | 0.79 | HTT (0.55) | MAPK1HTTNPSR1GAATDP1 | |
| SCHEMBL6846139 | 0.78 | MAPK1 (1.00) | MAPK1HTTNPSR1GAATDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997040020-A1 | PHTHALAZINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS DRUGS | SCHERING AKTIENGESELLSCHAFT (DE) | 1997-10-30 | — | — | WO | disclosed |