Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.80 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.80 |
| ▸ | APP | P05067 | 7/20 | 0.71 |
| ▸ | SHBG | P04278 | 1/20 | 0.59 |
| ▸ | PTGES | O14684 | 1/20 | 0.54 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | IP6K2 | Q9UHH9 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734509 | 1.00 | ESR1 (0.80) | ESR1ESR2APPSHBGPTGES | |
| SCHEMBL3930549 | 0.90 | ESR1 (0.74) | ESR1ESR2APPSHBGPTGES | |
| SCHEMBL3922677 | 0.89 | ESR1 (1.00) | ESR1ESR2APPSHBGPTGES | |
| SCHEMBL29941531 | 0.89 | ESR1 (1.00) | ESR1ESR2APPSHBGPTGES | |
| SCHEMBL733973 | 0.86 | SHBG (0.80) | ESR1ESR2APPSHBGHPGD | |
| SCHEMBL734501 | 0.86 | SHBG (0.80) | ESR1ESR2APPSHBGHPGD | |
| SCHEMBL30176923 | 0.86 | SHBG (0.80) | ESR1ESR2APPSHBGHPGD | |
| SCHEMBL734894 | 0.83 | ESR1 (0.80) | ESR1ESR2APPSHBGPTGES | |
| SCHEMBL28507078 | 0.83 | ESR1 (0.80) | ESR1ESR2APPSHBGPTGES | |
| SCHEMBL30207689 | 0.83 | ESR1 (0.80) | ESR1ESR2APPSHBGPTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120189545-A1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS | UNIVERSITY OF PITTSBURGH -- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2012-07-26 | — | — | US | disclosed |
| US-20120148494-A1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS | UNIVERSITY OF PITTSBURGH -- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2012-06-14 | — | — | US | disclosed |
| US-8138360-B2 | substrates for amyloidogenic proteins, for example, A beta 1-42, an amyloid protein, brain deposits of which are associated with Alzheimer's disease | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2012-03-20 | — | — | US | disclosed |
| US-20080274058-A1 | Isotopically-Labeled Benzofuran Compounds as Imaging Agents for Amyloidogenic Proteins | UNIVERSITY OF PITTSBURGH- OF COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2008-11-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120148494-A1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS | BACE1, APP, BACE2 | ESR1 2586/4885ESR2 1457/4885APP 2/4885 |
| US-20080274058-A1 | Isotopically-Labeled Benzofuran Compounds as Imaging Agents for Amyloidogenic Proteins | BACE1, APP, BACE2 | ESR1 2826/4885ESR2 1599/4885APP 2/4885 |
| US-20120189545-A1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS | BACE1, APP, BACE2 | ESR1 2826/4885ESR2 1599/4885APP 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.