Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.42 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.42 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.42 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL146167 | 0.95 | NPC1 (0.42) | RAB9ANPC1SMN1; SMN2PDE4APDE4B | |
| SCHEMBL144870 | 0.94 | ABCB1 (0.44) | RAB9ANPC1SMN1; SMN2PDE4APDE4B | |
| SCHEMBL147907 | 0.93 | ABCB1 (0.44) | RAB9ANPC1SMN1; SMN2PDE4APDE4B | |
| SCHEMBL142287 | 0.93 | LMNA (0.44) | RAB9ANPC1SMN1; SMN2PDE4APDE4B | |
| SCHEMBL141749 | 0.89 | PDE4A (0.47) | RAB9ANPC1SMN1; SMN2PDE4APDE4B | |
| SCHEMBL8440097 | 0.87 | PDE4D (0.44) | RAB9ANPC1SMN1; SMN2PDE4APDE4B | |
| SCHEMBL145586 | 0.86 | SMN1; SMN2 (0.45) | RAB9ANPC1SMN1; SMN2PDE4APDE4B | |
| SCHEMBL6690768 | 0.86 | PDE4D (0.44) | RAB9ANPC1SMN1; SMN2PDE4APDE4B | |
| SCHEMBL145110 | 0.86 | ABL1 (0.46) | RAB9ANPC1SMN1; SMN2PDE4APDE4B | |
| SCHEMBL145100 | 0.86 | PDE4A (0.42) | RAB9ANPC1SMN1; SMN2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0763534-A1 | Arylalkyl-diazinone derivatives as phosphodiesterase IV inhibitors | MERCK PATENT GmbH (DE) | 1997-03-19 | — | — | EP | disclosed |