Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | MAPT | P10636 | 4/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.49 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.49 |
| ▸ | RET | P07949 | 2/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 2/20 | 0.49 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.49 |
| ▸ | HTR1A | P08908 | 2/20 | 0.49 |
| ▸ | CHRM5 | P08912 | 2/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7126546 | 0.84 | KDM4E (0.60) | ALDH1A1MAPTSMN1; SMN2HTTHIF1A | |
| SCHEMBL7126540 | 0.84 | KDM4E (0.60) | ALDH1A1MAPTSMN1; SMN2HTTHIF1A | |
| SCHEMBL4786615 | 0.79 | MAP1LC3B (0.47) | ALDH1A1MAPTSMN1; SMN2HTTHIF1A | |
| SCHEMBL4786611 | 0.79 | MAP1LC3B (0.47) | ALDH1A1MAPTSMN1; SMN2HTTHIF1A | |
| SCHEMBL20229633 | 0.78 | PARP10 (0.43) | ALDH1A1MAPTSMN1; SMN2HTTHIF1A | |
| SCHEMBL21328476 | 0.78 | PARP10 (0.43) | ALDH1A1MAPTSMN1; SMN2HTTHIF1A | |
| SCHEMBL21328475 | 0.78 | PARP10 (0.43) | ALDH1A1MAPTSMN1; SMN2HTTHIF1A | |
| Trimethylammonium SCHEMBL27680388 | 0.77 | CYP2A6 (0.63) | ALDH1A1MAPTKDM4EMEN1KMT2A | |
| SCHEMBL11876812 | 0.77 | CES1 (0.52) | ALDH1A1MAPTSMN1; SMN2HTTKDM4E | |
| SCHEMBL14090173 | 0.76 | KMT2A (0.73) | ALDH1A1MAPTSMN1; SMN2HTTHIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |