Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 16/20 | 0.63 |
| ▸ | PDE1A | P54750 | 2/20 | 0.60 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.60 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 1/20 | 0.60 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.57 |
| ▸ | MTOR | P42345 | 1/20 | 0.50 |
| ▸ | PDE6C | P51160 | 3/20 | 0.49 |
| ▸ | PDE2A | O00408 | 1/20 | 0.49 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.49 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.49 |
| ▸ | PDE6D | O43924 | 1/20 | 0.49 |
| ▸ | PDE8A | O60658 | 1/20 | 0.49 |
| ▸ | PDE9A | O76083 | 1/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7343294 | 0.82 | KMT2A (0.53) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL7334441 | 0.79 | PDE5A (0.66) | PDE5APDE1APDE1BPDE1CPDE3B | |
| SCHEMBL31607151 | 0.77 | PDE5A (0.76) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL1529 | 0.77 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL18577846 | 0.77 | PDE5A (0.76) | PDE5APDE1APDE1BPDE1CKMT2A | |
| Oxirane SCHEMBL8190387 | 0.76 | PDE5A (0.64) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL3316795 | 0.76 | PDE5A (0.82) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL31174349 | 0.75 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL1202 | 0.75 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CKMT2A | |
| SCHEMBL6389085 | 0.74 | PDE5A (1.00) | PDE5APDE1APDE1BPDE1CKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057829-B1 | Novel compounds and pharmaceutical compositions containing the same | JORDANIAN PHARMACEUTICAL MFG A (JO) | 2002-11-20 | — | — | EP | disclosed |
| US-6242444-B1 | 5-(2,3-DIHYDRO-5-(4-METHYLPIPERAZIN-1-YLSULFONYL)-7-BENZOFURYL )-1-METHYL-3-PROPYL-6,7-DIHYDRO-1H-PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE, FOR EXAMPLE; TREATMENT OF INTER ALIA ERECTILE DYSFUNCTION. | THE JORDANIAN PHARMACEUTICAL MANUFACTURING AND MEDICAL EQUIPMENT CO., LTD. (JO) | 2001-06-05 | — | — | US | disclosed |
| EP-1057829-A1 | Novel compounds and pharmaceutical compositions containing the same | The Jordanian Pharmaceutical Manufacturing and Medical Equipment Co.Ltd. (JO) | 2000-12-06 | — | — | EP | disclosed |