Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | PDE5A | O76074 | 16/20 | 0.53 |
| ▸ | PDE3B | Q13370 | 4/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 4/20 | 0.53 |
| ▸ | PDE1A | P54750 | 2/20 | 0.53 |
| ▸ | PDE1B | Q01064 | 2/20 | 0.53 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.53 |
| ▸ | PDE2A | O00408 | 1/20 | 0.53 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.53 |
| ▸ | ABCC5 | O15440 | 1/20 | 0.53 |
| ▸ | PDE6D | O43924 | 1/20 | 0.53 |
| ▸ | PDE8A | O60658 | 1/20 | 0.53 |
| ▸ | PDE9A | O76083 | 1/20 | 0.53 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | PDE6A | P16499 | 1/20 | 0.53 |
| ▸ | PDE6G | P18545 | 1/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7334441 | 0.88 | PDE5A (0.66) | PDE5APDE3BPDE3APDE1APDE1B | |
| SCHEMBL7344890 | 0.82 | PDE5A (0.63) | KMT2APDE5APDE3BPDE3APDE1A | |
| SCHEMBL931 | 0.78 | PDE5A (0.68) | KMT2APDE5APDE3BPDE3APDE1A | |
| Oxirane SCHEMBL8190387 | 0.78 | PDE5A (0.64) | KMT2APDE5APDE3BPDE3APDE1A | |
| SCHEMBL3313876 | 0.77 | KMT2A (0.70) | KMT2APDE5APDE3BPDE3APDE1A | |
| SCHEMBL1071 | 0.76 | KMT2A (0.83) | KMT2APDE5APDE3BPDE3APDE1A | |
| SCHEMBL29655374 | 0.76 | KMT2A (0.83) | KMT2APDE5APDE3BPDE3APDE1A | |
| SCHEMBL6621924 | 0.76 | PDE5A (0.57) | KMT2APDE5APDE3BPDE3APDE1A | |
| SCHEMBL31202676 | 0.76 | KMT2A (0.73) | KMT2APDE5APDE3BPDE3APDE1A | |
| SCHEMBL1253 | 0.76 | KMT2A (0.73) | KMT2APDE5APDE3BPDE3APDE1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6242444-B1 | 5-(2,3-DIHYDRO-5-(4-METHYLPIPERAZIN-1-YLSULFONYL)-7-BENZOFURYL )-1-METHYL-3-PROPYL-6,7-DIHYDRO-1H-PYRAZOLO(4,3-D)PYRIMIDIN-7-ONE, FOR EXAMPLE; TREATMENT OF INTER ALIA ERECTILE DYSFUNCTION. | THE JORDANIAN PHARMACEUTICAL MANUFACTURING AND MEDICAL EQUIPMENT CO., LTD. (JO) | 2001-06-05 | — | — | US | disclosed |
| EP-1057829-A1 | Novel compounds and pharmaceutical compositions containing the same | The Jordanian Pharmaceutical Manufacturing and Medical Equipment Co.Ltd. (JO) | 2000-12-06 | — | — | EP | disclosed |