Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR4 | Q13639 | 20/20 | 0.85 |
| ▸ | HTR2A | P28223 | 9/20 | 0.85 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13220645 | 0.92 | HTR4 (1.00) | HTR4HTR2AKCNH2 | |
| Hydrochloric Acid SCHEMBL7341669 | 0.91 | HTR4 (1.00) | HTR4HTR2AKCNH2 | |
| SCHEMBL7342942 | 0.86 | HTR4 (1.00) | HTR4HTR2AKCNH2 | |
| SCHEMBL3042859 | 0.86 | HTR4 (1.00) | HTR4HTR2AKCNH2 | |
| Oxalic Acid SCHEMBL1405809 | 0.85 | HTR4 (1.00) | HTR4HTR2AKCNH2 | |
| Hydrochloric Acid SCHEMBL4413286 | 0.85 | HTR4 (1.00) | HTR4HTR2AKCNH2 | |
| SCHEMBL1405951 | 0.85 | HTR4 (0.98) | HTR4HTR2AKCNH2 | |
| SCHEMBL7345174 | 0.85 | HTR4 (1.00) | HTR4HTR2AKCNH2 | |
| Hydrochloric Acid SCHEMBL1405944 | 0.84 | HTR4 (1.00) | HTR4HTR2AKCNH2 | |
| Oxalic Acid SCHEMBL7400224 | 0.83 | HTR4 (0.71) | HTR4HTR2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0975623-B1 | INDAZOLE AMIDE COMPOUNDS AS SEROTONINERGIC AGENTS | ACRAF (IT) | 2002-06-19 | — | — | EP | disclosed |
| US-6197769-B1 | SEROTONINE RECEPTORS ANTAGONIST; GASTROINTESTINAL DISORDERS, ANTIARRHYTHMIA AGENTS; INCONTINENCE | AZIENDE CHIMICHE RIUNITE ANGELINI FRANCESCO A.C.R.A.F. S.P.A. (IT) | 2001-03-06 | — | — | US | disclosed |