Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.33 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.33 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.33 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.31 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | MMP13 | P45452 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CA7 | P43166 | 1/20 | 0.31 |
| ▸ | NOS1 | P29475 | 2/20 | 0.31 |
| ▸ | NOS3 | P29474 | 1/20 | 0.31 |
| ▸ | NOS2 | P35228 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18432601 | 0.84 | ALDH1A1 (0.37) | AAK1CHRNB2CHRNA4HDAC6HDAC1 | |
| SCHEMBL7351512 | 0.84 | AAK1 (0.34) | AAK1CHRNB2CHRNA4HDAC6HDAC1 | |
| SCHEMBL10473406 | 0.84 | AAK1 (0.34) | AAK1CHRNB2CHRNA4HDAC6HDAC1 | |
| SCHEMBL20225541 | 0.81 | AAK1 (0.37) | AAK1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL19226352 | 0.81 | AAK1 (0.37) | AAK1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL2581321 | 0.81 | AAK1 (0.38) | AAK1HDAC6HDAC1HDAC2MAOA | |
| SCHEMBL15443192 | 0.80 | AAK1 (0.34) | AAK1CHRNB2CHRNA4HDAC6HDAC1 | |
| SCHEMBL86238 | 0.79 | AAK1 (0.35) | AAK1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5565289 | 0.79 | AAK1 (0.35) | AAK1CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL25536966 | 0.79 | AAK1 (0.35) | AAK1CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0431520-B1 | Heterocyclic acyl aminodiol beta-amino acid derivatives | SEARLE & CO (US) | 1995-02-08 | — | — | EP | disclosed |
| US-5290787-A | Renin inhibitors; hypotensive agents | G. D. SEARLE & CO. (US) | 1994-03-01 | — | — | US | disclosed |
| US-5283250-A | Renin inhibitor;hypotensive agent | G. D. SEARLE & CO. (US) | 1994-02-01 | — | — | US | disclosed |
| US-5231111-A | Imidazolyl/imidazolylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives | G. D. SEARLE & CO. (US) | 1993-07-27 | — | — | US | disclosed |
| US-5223532-A | Chromonyl/chromonylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino derivatives | G. D. SEARLE & CO. (US) | 1993-06-29 | — | — | US | disclosed |
| US-5223512-A | Renin inhibitors, hypotensive agents | G. D. SEARLE & CO. (US) | 1993-06-29 | — | — | US | disclosed |
| US-5223514-A | Renin inhibiros, hypotensive agents | G. D. SEARLE & CO. (US) | 1993-06-29 | — | — | US | disclosed |
| US-5223534-A | Renin inhibitors, hypotensive agents | G. D. SEARLE & CO. (US) | 1993-06-29 | — | — | US | disclosed |
| US-5217991-A | Renin inhibitors for treating hypertension | G. D. SEARLE & CO. (US) | 1993-06-08 | — | — | US | disclosed |
| US-5217989-A | Benothiophenyl/benzothiophenylalkyl-N-terminal cycloalkoxy-C-terminal amino hydroxy β-amino acid derivatives | G. D. SEARLE & CO. (US) | 1993-06-08 | — | — | US | disclosed |
| US-5212174-A | Renin inhibitors for hypotensive agents | G. D. SEARLE & CO. (US) | 1993-05-18 | — | — | US | disclosed |
| US-5212175-A | Benzothiophenyl benzothiophenylalkyl-N-terminal amino hydroxy β-amino acid derivatives | G. D. SEARLE & CO. (US) | 1993-05-18 | — | — | US | disclosed |
| US-5210095-A | Renin inhibiting compound for treatment of hypertension | G. D. SEARLE & CO. (US) | 1993-05-11 | — | — | US | disclosed |
| US-5180725-A | Renin inhibitors | G. D. SEARLE & CO. (US) | 1993-01-19 | — | — | US | disclosed |
| US-5180744-A | Renin inhibitors; hypotensive agents | G. D. SEARLE & CO. (US) | 1993-01-19 | — | — | US | disclosed |
| US-5179102-A | Naphthyridinyl/naphthyridinylalkyl-n-terminal anino hydroxy β-amino acid derivatives | G. D. SEARLE & CO. (US) | 1993-01-12 | — | — | US | disclosed |
| US-5175170-A | Renin inhibitors, hypotensive agents | G. D. SEARLE & CO. (US) | 1992-12-29 | — | — | US | disclosed |
| US-5175181-A | Renin inhibitors, hypotensive agents | G. D. SEARLE & CO. (US) | 1992-12-29 | — | — | US | disclosed |
| US-5171751-A | Renin inhibitors, hypotensive agents | G. D. SEARLE & CO. (US) | 1992-12-15 | — | — | US | disclosed |
| US-5147888-A | Hypotensive agents; renin inhibitors | G. D. SEARLE & CO. (US) | 1992-09-15 | — | — | US | disclosed |