Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
| ▸ | XDH | P47989 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14616750 | 0.89 | NOTUM (0.53) | NOTUMCYP2C9ALDH1A1MAPTTSHR | |
| SCHEMBL31238876 | 0.86 | MAPT (0.57) | NOTUMCYP2C9ALDH1A1MAPTTSHR | |
| SCHEMBL4580602 | 0.86 | MAPT (0.57) | NOTUMCYP2C9ALDH1A1MAPTTSHR | |
| SCHEMBL2934710 | 0.86 | MAPT (0.57) | NOTUMCYP2C9ALDH1A1MAPTTSHR | |
| SCHEMBL31336381 | 0.86 | MAPT (0.57) | NOTUMCYP2C9ALDH1A1MAPTTSHR | |
| SCHEMBL3904698 | 0.84 | NOTUM (0.57) | NOTUMALDH1A1MAPTCA12CA1 | |
| SCHEMBL6134609 | 0.83 | NOTUM (0.50) | NOTUMCYP2C9ALDH1A1MAPTCA12 | |
| SCHEMBL14448997 | 0.83 | NOTUM (0.47) | NOTUMCYP2C9ALDH1A1MAPTTSHR | |
| SCHEMBL2314446 | 0.83 | NOTUM (0.47) | NOTUMCYP2C9ALDH1A1MAPTCA12 | |
| SCHEMBL18822403 | 0.82 | PTGS2 (0.50) | NOTUMMAPTTSHRCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5648368-A | ANTICOAGULANTS | MERCK & CO., INC. (US) | 1997-07-15 | — | — | US | disclosed |
| EP-0673247-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS. | MERCK & CO INC (US) | 1996-05-01 | — | — | EP | disclosed |
| EP-0540334-B1 | Fibrinogen receptor antagonists | MERCK & CO INC (US) | 1996-01-03 | — | — | EP | disclosed |
| EP-0673247-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1995-09-27 | — | — | EP | disclosed |
| WO-1995017397-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1995-06-29 | — | — | WO | disclosed |
| US-5416099-A | Fibrinogen receptor antagonists | MERCK & CO., INC. (US) | 1995-05-16 | — | — | US | disclosed |
| US-5389631-A | A piperidinyl quinazoline or 1,3-benzodiazepine antiagglomerants of blood | MERCK & CO., INC. (US) | 1995-02-14 | — | — | US | disclosed |
| WO-1994012181-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1994-06-09 | — | — | WO | disclosed |
| US-5272158-A | Fibrinogen receptor antagonists | MERCK & CO., INC. (US) | 1993-12-21 | — | — | US | disclosed |
| EP-0540334-A1 | Fibrinogen receptor antagonists | MERCK & CO. INC. (US) | 1993-05-05 | — | — | EP | disclosed |