Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | MEN1 | O00255 | 2/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.60 |
| ▸ | GAA | P10253 | 1/20 | 0.60 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.60 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30969294 | 0.81 | POLB (0.70) | ATMKMT2AMEN1LMNAGAA | |
| SCHEMBL14587230 | 0.81 | ATM (0.63) | ATMKMT2AMEN1LMNAGAA | |
| SCHEMBL7346193 | 0.80 | HDAC6 (0.41) | ATMKMT2AMEN1LMNAGAA | |
| SCHEMBL12167622 | 0.79 | LMNA (0.90) | ATMKMT2AMEN1LMNAGAA | |
| SCHEMBL7348711 | 0.78 | HDAC6 (0.45) | ATMKMT2AMEN1 | |
| SCHEMBL1409602 | 0.78 | LMNA (0.65) | ATMKMT2AMEN1LMNAGAA | |
| SCHEMBL8288400 | 0.78 | LMNA (0.68) | ATMKMT2AMEN1LMNAGAA | |
| SCHEMBL7343435 | 0.77 | CACNA2D1 (0.46) | LMNAGAASMN1; SMN2ALDH1A1RAB9A | |
| SCHEMBL31559143 | 0.76 | GAA (0.67) | ATMKMT2AMEN1LMNAGAA | |
| SCHEMBL31559145 | 0.76 | GAA (0.67) | ATMKMT2AMEN1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0658157-A1 | DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS | MERRELL PHARMACEUTICALS INC. (US) | 1995-06-21 | — | — | EP | disclosed |
| WO-1994005648-A1 | DIARYL PIPERAZINOACETAMIDE COMPOUNDS AS ANTIMUSCARINIC AGENTS | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-17 | — | — | WO | disclosed |
| EP-0585500-A1 | Diaryl piperazineacetamides as antimuscarinic agents | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-03-09 | — | — | EP | disclosed |