Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 20/20 | 0.51 |
| ▸ | ITGAV | P06756 | 18/20 | 0.51 |
| ▸ | ITGB6 | P18564 | 17/20 | 0.51 |
| ▸ | ITGB1 | P05556 | 8/20 | 0.46 |
| ▸ | ITGA5 | P08648 | 8/20 | 0.46 |
| ▸ | ITGB5 | P18084 | 8/20 | 0.46 |
| ▸ | ITGB8 | P26012 | 8/20 | 0.46 |
| ▸ | ITGA8 | P53708 | 8/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Trifluoroacetic Acid SCHEMBL6777786 | 0.95 | ITGB3 (0.49) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL6779336 | 0.94 | ITGB3 (0.49) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL6773288 | 0.90 | ITGB3 (0.52) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL6780556 | 0.90 | ITGB3 (0.52) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL6777948 | 0.90 | ITGB3 (0.55) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL6773766 | 0.89 | F7 (0.48) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL6779560 | 0.88 | ITGB3 (0.50) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL15456810 | 0.87 | ITGB3 (0.54) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL15456294 | 0.87 | ITGB3 (0.54) | ITGB3ITGAVITGB6ITGB1ITGA5 | |
| SCHEMBL6777790 | 0.87 | ITGB3 (0.41) | ITGB3ITGAVITGB6ITGB1ITGA5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-B1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | SEARLE & CO (US) | 2001-07-18 | — | — | EP | claimed |
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |