Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | STS | P08842 | 1/20 | 0.39 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | ACHE | P22303 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17608848 | 0.79 | NPFFR1 (0.46) | SMN1; SMN2USP2OPRD1OPRK1ALDH1A1 | |
| SCHEMBL4321471 | 0.78 | STS (0.39) | SMN1; SMN2KMT2ASTSOPRD1OPRK1 | |
| SCHEMBL14665087 | 0.78 | — | — | |
| SCHEMBL13452646 | 0.78 | SMN1; SMN2 (0.47) | SMN1; SMN2MEN1KMT2AUSP2NPSR1 | |
| SCHEMBL6039864 | 0.76 | JAK2 (0.43) | SMN1; SMN2STSOPRD1OPRK1GAA | |
| SCHEMBL34467360 | 0.74 | MEN1 (0.51) | SMN1; SMN2MEN1KMT2AUSP2NPSR1 | |
| SCHEMBL28941207 | 0.73 | STS (0.40) | STSOPRD1OPRK1GPR119JAK2 | |
| SCHEMBL1843456 | 0.72 | — | — | |
| SCHEMBL14828673 | 0.72 | OPRD1 (0.43) | OPRD1OPRK1 | |
| SCHEMBL15552400 | 0.72 | MEN1 (0.43) | SMN1; SMN2MEN1KMT2ANPSR1CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992003429-A1 | RENIN INHIBITORS | ABBOTT LABORATORIES (US) | 1992-03-05 | — | — | WO | disclosed |