Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | CACNA1B | Q00975 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | CTSB | P07858 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | GFER | P55789 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | PREP | P48147 | 2/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7345914 | 1.00 | POLB (0.52) | POLBCACNA1BMEN1KMT2ARECQL | |
| SCHEMBL7346506 | 0.87 | MEN1 (0.60) | POLBCACNA1BMEN1KMT2ACTSL | |
| SCHEMBL7346514 | 0.87 | MEN1 (0.60) | POLBCACNA1BMEN1KMT2ACTSL | |
| SCHEMBL7037597 | 0.85 | CACNA1B (0.60) | POLBCACNA1BCTSLCTSKGAA | |
| SCHEMBL7037594 | 0.85 | CACNA1B (0.60) | POLBCACNA1BCTSLCTSKGAA | |
| SCHEMBL7342473 | 0.85 | CACNA1B (0.60) | POLBCACNA1BCTSLCTSKGAA | |
| SCHEMBL7340839 | 0.84 | MEN1 (0.56) | CACNA1BMEN1KMT2ACTSLCTSB | |
| SCHEMBL7340842 | 0.84 | MEN1 (0.56) | CACNA1BMEN1KMT2ACTSLCTSB | |
| SCHEMBL7337804 | 0.83 | POLB (0.60) | POLBCYP3A4CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7337799 | 0.83 | POLB (0.60) | POLBCYP3A4CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458781-B1 | BLOCKERS CALCIUM CHANNEL ANTAGONISTS FOR STROKES, BRAIN DISORDERS | WARNER-LAMBERT COMPANY | 2002-10-01 | — | — | US | disclosed |
| US-6423689-B1 | Peptidyl calcium channel blockers | WARNER-LAMBERT COMPANY | 2002-07-23 | — | — | US | disclosed |