Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | CTSL | P07711 | 3/20 | 0.49 |
| ▸ | CTSB | P07858 | 3/20 | 0.49 |
| ▸ | CTSS | P25774 | 2/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CTSK | P43235 | 2/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.46 |
| ▸ | CACNA1B | Q00975 | 2/20 | 0.45 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340839 | 1.00 | MEN1 (0.56) | MEN1KMT2ACYP2D6CYP2C9CYP3A4 | |
| SCHEMBL7346506 | 0.89 | MEN1 (0.60) | MEN1KMT2ACYP2D6CYP2C9CYP3A4 | |
| SCHEMBL7346514 | 0.89 | MEN1 (0.60) | MEN1KMT2ACYP2D6CYP2C9CYP3A4 | |
| SCHEMBL7345922 | 0.84 | POLB (0.52) | MEN1KMT2ACYP2D6CYP2C9CYP3A4 | |
| SCHEMBL7345914 | 0.84 | POLB (0.52) | MEN1KMT2ACYP2D6CYP2C9CYP3A4 | |
| SCHEMBL7037597 | 0.80 | CACNA1B (0.60) | CTSLCTSSCTSKCACNA1B | |
| SCHEMBL7037594 | 0.80 | CACNA1B (0.60) | CTSLCTSSCTSKCACNA1B | |
| SCHEMBL7342473 | 0.80 | CACNA1B (0.60) | CTSLCTSSCTSKCACNA1B | |
| SCHEMBL29588195 | 0.80 | MEN1 (0.61) | MEN1KMT2ACYP2D6CYP2C9CYP3A4 | |
| SCHEMBL22346418 | 0.79 | CTSL (0.55) | MEN1KMT2ACYP2D6CYP2C9CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6458781-B1 | BLOCKERS CALCIUM CHANNEL ANTAGONISTS FOR STROKES, BRAIN DISORDERS | WARNER-LAMBERT COMPANY | 2002-10-01 | — | — | US | disclosed |
| US-6423689-B1 | Peptidyl calcium channel blockers | WARNER-LAMBERT COMPANY | 2002-07-23 | — | — | US | disclosed |
| WO-1999055688-A1 | SUBSTITUTED DIARYLALKYL AMIDES AS CALCIUM CHANNEL ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1999-11-04 | — | — | WO | disclosed |