Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRD5A1 | P18405 | 1/20 | 0.38 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | TYMS | P04818 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | GSR | P00390 | 1/20 | 0.34 |
| ▸ | MIF | P14174 | 2/20 | 0.34 |
| ▸ | MITF | O75030 | 1/20 | 0.34 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7339006 | 0.81 | NOTUM (0.44) | SRD5A1SRD5A2NOTUMCES1TYMS | |
| SCHEMBL7345932 | 0.77 | CES1 (0.40) | SRD5A1SRD5A2NOTUMCES1TYMS | |
| SCHEMBL7342355 | 0.77 | CES1 (0.40) | SRD5A1SRD5A2NOTUMCES1TYMS | |
| SCHEMBL7340881 | 0.76 | KDM4E (0.54) | SRD5A1SRD5A2NOTUMCES1RAB9A | |
| SCHEMBL7338264 | 0.76 | TYMS (0.46) | SRD5A1SRD5A2CES1TYMSRAB9A | |
| SCHEMBL7336897 | 0.76 | CES1 (0.44) | SRD5A1SRD5A2CES1TYMSRAB9A | |
| Hydrochloric Acid SCHEMBL7337010 | 0.76 | CES1 (0.39) | SRD5A1SRD5A2NOTUMCES1TYMS | |
| SCHEMBL7342347 | 0.73 | CES1 (0.44) | SRD5A1SRD5A2CES1TYMSRAB9A | |
| SCHEMBL7345410 | 0.72 | KDM4E (0.48) | SRD5A1SRD5A2CES1TYMSRAB9A | |
| SCHEMBL7348534 | 0.71 | NPC1 (0.53) | SRD5A1SRD5A2TYMSRAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4511569-A | Tricyclic lactams and derivatives useful in increasing cardiac contractility | SCHERING CORPORATION (US) | 1985-04-16 | — | — | US | disclosed |
| EP-0102046-A1 | Tricyclic lactams, method for making them, pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1984-03-07 | — | — | EP | disclosed |