SCHEMBL7346103

SCHEMBL7346103

CCCCCN1CCC[N]c2ccccc21

nearest known ligand 0.47

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.47
MEN1 O00255 2/20 0.43
KMT2A Q03164 2/20 0.43
CYP2D6 P10635 3/20 0.43
CYP1A2 P05177 2/20 0.43
KDM4E B2RXH2 1/20 0.40
LMNA P02545 1/20 0.40
CYP2C19 P33261 2/20 0.39
HTR1A P08908 1/20 0.39
CYP3A4 P08684 1/20 0.39
EEF2K O00418 1/20 0.36
ALDH2 P05091 1/20 0.36
ALDH3A1 P30838 1/20 0.36
CES1 P23141 2/20 0.35
CDC25A P30304 1/20 0.35
TLR8 Q9NR97 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7346424 0.99 ALDH1A1 (0.49) ALDH1A1MEN1KMT2ACYP2D6CYP1A2
SCHEMBL7351284 0.95 CYP2D6 (0.47) ALDH1A1MEN1KMT2ACYP2D6CYP1A2
SCHEMBL6196442 0.91 MEN1 (0.45) ALDH1A1MEN1KMT2ACYP2D6CYP1A2
SCHEMBL7353592 0.90 MEN1 (0.47) ALDH1A1MEN1KMT2ACYP2D6CYP1A2
SCHEMBL7351385 0.89 ALDH1A1 (0.54) ALDH1A1MEN1KMT2ACYP2D6CYP1A2
SCHEMBL7345538 0.86 CYP2D6 (0.43) ALDH1A1MEN1KMT2ACYP2D6CYP1A2
SCHEMBL7345950 0.80 ALDH1A1 (0.49) ALDH1A1MEN1KMT2ACYP2D6CYP1A2
SCHEMBL19949917 0.77 KDM4E (0.51) ALDH1A1MEN1KMT2ACYP2D6CYP1A2
SCHEMBL7352444 0.74 CYP2D6 (0.36) ALDH1A1MEN1KMT2ACYP2D6CYP1A2
SCHEMBL5668195 0.74 ALDH1A1 (0.77) ALDH1A1MEN1KMT2AKDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0450097-B1 BENZOHETEROCYCLIC COMPOUNDS OTSUKA PHARMA CO LTD (JP) 1996-04-24 EP claimed
US-5985869-A USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1999-11-16 US disclosed
US-5753677-A Benzoheterocyclic compounds OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1998-05-19 US disclosed
US-5559230-A VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1996-09-24 US disclosed
EP-0450097-B1 BENZOHETEROCYCLIC COMPOUNDS OTSUKA PHARMA CO LTD (JP) 1996-04-24 EP disclosed
EP-0602209-A1 OXYTOCIN ANTAGONIST OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1994-06-22 EP disclosed
WO-1994001113-A1 OXYTOCIN ANTAGONIST OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) 1994-01-20 WO disclosed
EP-0450097-A1 BENZOHETEROCYCLIC COMPOUNDS. OTSUKA PHARMA CO LTD (JP) 1991-10-09 EP disclosed
WO-1991005549-A1 BENZOHETEROCYCLIC COMPOUNDS OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1991-05-02 WO disclosed