Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 16/20 | 1.00 |
| ▸ | DRD2 | P14416 | 4/20 | 0.60 |
| ▸ | DRD3 | P35462 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9205468 | 0.86 | HTR1A (0.76) | HTR1ADRD2DRD3 | |
| SCHEMBL7342945 | 0.86 | HTR1A (0.76) | HTR1ADRD2DRD3 | |
| SCHEMBL7350794 | 0.84 | HTR1A (0.73) | HTR1ADRD2DRD3 | |
| SCHEMBL7341929 | 0.84 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| SCHEMBL7381621 | 0.80 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| SCHEMBL7345025 | 0.76 | HTR1A (0.62) | HTR1ADRD2DRD3 | |
| SCHEMBL6352686 | 0.76 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| SCHEMBL7343418 | 0.75 | HTR1A (1.00) | HTR1ADRD2DRD3 | |
| Hydrochloric Acid SCHEMBL9129339 | 0.73 | HTR1A (0.60) | HTR1ADRD2DRD3 | |
| SCHEMBL6361652 | 0.73 | HTR1A (1.00) | HTR1ADRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436240-A | Schizophrenia, Parkinson's disease, depression or hypotensive agents using tricyclic amines | THE UPJOHN COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| EP-0480939-B1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | UPJOHN CO (US) | 1995-01-25 | — | — | EP | disclosed |
| US-5273975-A | Heterocyclic amines having central nervous system activity | THE UPJOHN COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| WO-1990015058-A1 | HETEROCYCLIC AMINES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY | THE UPJOHN COMPANY (US) | 1990-12-13 | — | — | WO | disclosed |