SCHEMBL7347186

SCHEMBL7347186

O=C(C[C@H](CCN1C(=O)c2ccccc2C1=O)C(=O)O)c1ccc(-c2ccc(Cl)cc2)cc1

nearest known ligand 0.59

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
MMP2 P08253 17/20 0.59
MMP9 P14780 17/20 0.59
MMP3 P08254 4/20 0.56
MMP13 P45452 3/20 0.56
MMP1 P03956 2/20 0.56
MMP8 P22894 1/20 0.56
TSHR P16473 1/20 0.44
RECQL P46063 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7378575 1.00 MMP2 (0.59) MMP2MMP9MMP3MMP13MMP1
SCHEMBL4654577 1.00 MMP2 (0.59) MMP2MMP9MMP3MMP13MMP1
SCHEMBL9248117 0.93 MMP2 (0.61) MMP2MMP9MMP3MMP13MMP1
SCHEMBL12300384 0.93 MMP2 (0.61) MMP2MMP9MMP3MMP13MMP1
SCHEMBL2380986 0.93 MMP2 (0.61) MMP2MMP9MMP3MMP13MMP1
SCHEMBL6291932 0.89 MMP2 (0.48) MMP2MMP9MMP3MMP13MMP1
SCHEMBL6296089 0.88 GSK3B (0.55) MMP2MMP9MMP3MMP13MMP1
SCHEMBL7865124 0.88 TSHR (0.58) MMP2MMP9MMP3MMP13MMP1
SCHEMBL8504009 0.87 MMP2 (0.55) MMP2MMP9MMP3MMP13MMP1
SCHEMBL7639741 0.85 CYP1B1 (0.47) MMP2MMP9MMP3MMP13MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0790974-B1 SUBSTITUTED 4-BIARYLBUTYRIC OR 5-BIARYLPENTANOIC ACIDS AND DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITIORS BAYER AG (US) 2002-08-14 EP claimed
WO-1996015096-A1 SUBSTITUTED 4-BIARYLBUTYRIC OR 5-BIARYLPENTANOIC ACIDS AND DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITIORS BAYER CORPORATION (US) 1996-05-23 WO claimed
CN-1371286-A Use of cyclooxygenase-2 inhibitor matrix metallappoteinase inhibitor antineoplastic agent and optionally radiation as combination treatment of neoplasia SEARLE & CO (US) 2002-09-25 CN disclosed
EP-0790974-B1 SUBSTITUTED 4-BIARYLBUTYRIC OR 5-BIARYLPENTANOIC ACIDS AND DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITIORS BAYER AG (US) 2002-08-14 EP disclosed
EP-0937036-B1 SUBSTITUTED 4-BIPHENYL-4-HYDROXYBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS BAYER AG (US) 2001-12-05 EP disclosed
US-6166082-A Substituted 5-biarylpentanoic acids and derivatives as matrix metalloprotease inhibitors BAYER CORPORATION (US) 2000-12-26 US disclosed
EP-0937036-A1 SUBSTITUTED 4-BIPHENYL-4-HYDROXYBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS Bayer Corporation (US) 1999-08-25 EP disclosed
WO-1998022436-A1 SUBSTITUTED 4-BIPHENYL-4-HYDROXYBUTYRIC ACID DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITORS BAYER CORPORATION (US) 1998-05-28 WO disclosed
EP-0790974-A1 SUBSTITUTED 4-BIARYLBUTYRIC OR 5-BIARYLPENTANOIC ACIDS AND DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITIORS Bayer Corporation (US) 1997-08-27 EP disclosed
WO-1996015096-A1 SUBSTITUTED 4-BIARYLBUTYRIC OR 5-BIARYLPENTANOIC ACIDS AND DERIVATIVES AS MATRIX METALLOPROTEASE INHIBITIORS BAYER CORPORATION (US) 1996-05-23 WO disclosed