Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.58 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.58 |
| ▸ | ESR2 | Q92731 | 4/20 | 0.54 |
| ▸ | ESR1 | P03372 | 3/20 | 0.54 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | CLK1 | P49759 | 2/20 | 0.47 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.47 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.47 |
| ▸ | SULT1A1 | P50225 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 2/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.46 |
| ▸ | BCR | P11274 | 2/20 | 0.46 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6171301 | 0.88 | ESR2 (0.68) | APPHDAC6ESR2ESR1SULT1A1 | |
| SCHEMBL9151832 | 0.84 | BACE1 (0.56) | HDAC6ESR2ESR1BACE1CLK1 | |
| SCHEMBL23815138 | 0.81 | ESR1 (0.72) | APPESR2ESR1CLK1DYRK1A | |
| SCHEMBL498648 | 0.81 | ESR2 (0.73) | APPHDAC6ESR2ESR1SULT1A1 | |
| SCHEMBL21014552 | 0.79 | HDAC6 (0.49) | APPHDAC6BACE1CLK1DYRK1A | |
| SCHEMBL1179171 | 0.77 | HDAC6 (0.60) | HDAC6CLK1DYRK1ADYRK1BNPC1 | |
| SCHEMBL1665299 | 0.77 | NPC1 (0.56) | APPHDAC6ESR2ESR1CA2 | |
| SCHEMBL31310542 | 0.77 | NPC1 (0.56) | APPHDAC6ESR2ESR1CA2 | |
| SCHEMBL7349045 | 0.76 | FFAR4 (0.58) | HDAC6CLK1DYRK1ADYRK1BALDH1A1 | |
| SCHEMBL6173418 | 0.76 | RAB9A (0.68) | APPHDAC6CA2NPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0993300-A4 | ANTITHROMBOTIC AGENTS | LILLY CO ELI (US) | 2002-07-31 | — | — | EP | disclosed |
| US-6284756-B1 | ANTICOAGULANT | ELI LILLY AND COMPANY | 2001-09-04 | — | — | US | disclosed |
| EP-0993300-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 2000-04-19 | — | — | EP | disclosed |
| WO-1998048798-A1 | ANTITHROMBOTIC AGENTS | ELI LILLY AND COMPANY (US) | 1998-11-05 | — | — | WO | disclosed |