Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA3 | P22001 | 1/20 | 0.63 |
| ▸ | HTR1B | P28222 | 8/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.58 |
| ▸ | HRH1 | P35367 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HTR1D | P28221 | 1/20 | 0.53 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.51 |
| ▸ | HTR2A | P28223 | 2/20 | 0.51 |
| ▸ | HTR7 | P34969 | 2/20 | 0.51 |
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7347274 | 0.98 | KCNA3 (0.61) | KCNA3HTR1BSLC6A4HRH1TDP1 | |
| SCHEMBL7162391 | 0.95 | HTR1B (0.62) | KCNA3HTR1BSLC6A4HRH1TDP1 | |
| SCHEMBL7352198 | 0.90 | HTR1B (0.61) | KCNA3HTR1BSLC6A4HRH1TDP1 | |
| SCHEMBL9770352 | 0.86 | KCNA3 (0.81) | KCNA3HTR1BSLC6A4HRH1TDP1 | |
| SCHEMBL16902852 | 0.84 | KCNA3 (0.79) | KCNA3HTR1BSLC6A4HRH1TDP1 | |
| SCHEMBL16902849 | 0.84 | KCNA3 (0.79) | KCNA3HTR1BSLC6A4HRH1TDP1 | |
| SCHEMBL16902854 | 0.84 | KCNA3 (0.79) | KCNA3HTR1BSLC6A4HRH1TDP1 | |
| SCHEMBL16902840 | 0.84 | KCNA3 (0.79) | KCNA3HTR1BSLC6A4HRH1TDP1 | |
| SCHEMBL16902853 | 0.84 | KCNA3 (0.79) | KCNA3HTR1BSLC6A4HRH1TDP1 | |
| SCHEMBL16902855 | 0.84 | KCNA3 (0.79) | KCNA3HTR1BSLC6A4HRH1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5985869-A | USEFUL AS VASODILATORS, HYPOTENSIVE AGENTS, WATER DIURETICS, PLATELET AGGLUTINATION INHIBITORS | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1999-11-16 | — | — | US | disclosed |
| US-5753677-A | Benzoheterocyclic compounds | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1998-05-19 | — | — | US | disclosed |
| US-5559230-A | VASOPRESSIN ANTAGONISTS, QUINOLINES, BENZAZEPINES, VASODILATION, HYPOTENSIVE AGENTS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1996-09-24 | — | — | US | disclosed |
| EP-0450097-B1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMA CO LTD (JP) | 1996-04-24 | — | — | EP | disclosed |
| CN-1091288-A | The oxytocin antagonist | OTSUKA PHARMA CO LTD (JP) | 1994-08-31 | — | — | CN | disclosed |
| EP-0602209-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1994-06-22 | — | — | EP | disclosed |
| WO-1994001113-A1 | OXYTOCIN ANTAGONIST | OTSUKA PHARMACEUTICAL COMPANY, LIMITED (JP) | 1994-01-20 | — | — | WO | disclosed |
| EP-0450097-A1 | BENZOHETEROCYCLIC COMPOUNDS. | OTSUKA PHARMA CO LTD (JP) | 1991-10-09 | — | — | EP | disclosed |
| WO-1991005549-A1 | BENZOHETEROCYCLIC COMPOUNDS | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 1991-05-02 | — | — | WO | disclosed |