Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | DRD3 | P35462 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | NSD2 | O96028 | 1/20 | 0.35 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349237 | 0.82 | SLC6A2 (0.50) | DRD2DRD3SLC6A2SLC6A4SMN1; SMN2 | |
| SCHEMBL7352583 | 0.81 | DRD3 (0.51) | DRD2DRD3SLC6A2SLC6A4CHEK1 | |
| SCHEMBL7351591 | 0.79 | DRD3 (0.49) | DRD2DRD3SLC6A2SLC6A4CYP2D6 | |
| SCHEMBL7382584 | 0.74 | DRD2 (0.55) | DRD2DRD3SLC6A2SLC6A4MEN1 | |
| SCHEMBL7382004 | 0.71 | DRD2 (0.51) | DRD2DRD3SLC6A2SLC6A4MEN1 | |
| SCHEMBL2374998 | 0.70 | CTSC (0.40) | MEN1KMT2AUSP2NSD2NSD3 | |
| SCHEMBL2374755 | 0.69 | NPC1 (0.46) | MEN1KMT2ACYP2C19ALDH1A1HPGD | |
| SCHEMBL1858677 | 0.67 | SLC6A2 (0.48) | DRD2DRD3SLC6A2SLC6A4CYP2D6 | |
| SCHEMBL3595094 | 0.67 | SLC6A2 (0.48) | DRD2DRD3SLC6A2SLC6A4CYP2D6 | |
| SCHEMBL1858679 | 0.67 | SLC6A2 (0.48) | DRD2DRD3SLC6A2SLC6A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5594024-A | ANTIDEPRESSANTS; TREATMENT OF NARCOLEPSY, SCHIZOPHRENIA, DRUG ABUSE | THE UPJOHN COMPANY (US) | 1997-01-14 | — | — | US | disclosed |
| US-5462947-A | Nervous system disorders | THE UPJOHN COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0641320-A1 | NEW CENTRALLY ACTING SUBSTITUTED PHENYLAZACYCLOALKANES | PHARMACIA & UPJOHN COMPANY (US) | 1995-03-08 | — | — | EP | disclosed |
| WO-1992018475-A2 | SUBSTITUTED PHENYLAZACYCLOALKANES AS CNS AGENTS | THE UPJOHN COMPANY (US) | 1992-10-29 | — | — | WO | disclosed |