Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 4/20 | 0.48 |
| ▸ | ITGA2B | P08514 | 2/20 | 0.48 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.45 |
| ▸ | ITGB1 | P05556 | 3/20 | 0.45 |
| ▸ | ITGAV | P06756 | 3/20 | 0.45 |
| ▸ | MDM4 | O15151 | 2/20 | 0.45 |
| ▸ | ITGA5 | P08648 | 2/20 | 0.45 |
| ▸ | MDM2 | Q00987 | 2/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.41 |
| ▸ | ITGB5 | P18084 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.40 |
| ▸ | PPARD | Q03181 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.40 |
| ▸ | F2 | P00734 | 2/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7348423 | 0.88 | ITGB3 (0.45) | ITGB3ITGA2BTAOK1ITGB1ITGAV | |
| SCHEMBL7346500 | 0.86 | ITGB3 (0.60) | ITGB3ITGA2BITGB1ITGAVRXFP1 | |
| SCHEMBL6778210 | 0.85 | ITGB3 (0.45) | ITGB3ITGA2BTAOK1ITGB1ITGAV | |
| SCHEMBL7337027 | 0.83 | RXFP1 (0.43) | ITGB3ITGA2BITGB1ITGAVMDM4 | |
| SCHEMBL7348081 | 0.82 | ITGB3 (0.43) | ITGB3ITGA2BITGB1ITGAVMDM4 | |
| SCHEMBL7348024 | 0.81 | ITGB3 (0.42) | ITGB3ITGA2BITGB1ITGAVMDM4 | |
| SCHEMBL7340337 | 0.80 | ITGB3 (0.41) | ITGB3ITGA2BITGB1ITGAVMDM4 | |
| SCHEMBL6777380 | 0.79 | SMN1; SMN2 (0.44) | ITGB3ITGA2BITGB1ITGAVMDM4 | |
| SCHEMBL7340290 | 0.79 | ITGB3 (0.42) | ITGB3ITGA2BITGB1ITGAVMDM4 | |
| SCHEMBL7339868 | 0.79 | RXFP1 (0.45) | ITGB3TAOK1ITGB1ITGAVMDM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850221-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1998-07-01 | — | — | EP | claimed |
| WO-1997008145-A1 | META-GUANIDINE, UREA, THIOUREA OR AZACYCLIC AMINO BENZOIC ACID DERIVATIVES AS INTEGRIN ANTAGONISTS | G.D. SEARLE & CO. (US) | 1997-03-06 | — | — | WO | claimed |