⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15133471 | 0.82 | — | — | |
| SCHEMBL22100957 | 0.78 | EPHX1 (0.46) | — | |
| SCHEMBL9273406 | 0.78 | EPHX1 (0.46) | — | |
| SCHEMBL5019145 | 0.78 | PRMT3 (0.53) | — | |
| SCHEMBL13542552 | 0.78 | — | — | |
| SCHEMBL15426781 | 0.75 | — | — | |
| SCHEMBL16781964 | 0.73 | PRMT3 (0.65) | — | |
| SCHEMBL48539 | 0.73 | — | — | |
| SCHEMBL1697723 | 0.73 | PRMT1 (0.65) | — | |
| SCHEMBL25590398 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230167110-A1 | 6-HETEROARYLOXY BENZIMIDAZOLES AND AZABENZIMIDAZOLES AS JAK2 INHIBITORS | SCHRÖDINGER, INC. | 2023-06-01 | — | — | US | disclosed |
| US-11541047-B2 | Dosages of immunoconjugates of antibodies and SN-38 for improved efficacy and decreased toxicity | IMMUNOMEDICS, INC. (US) | 2023-01-03 | — | — | US | disclosed |
| WO-2021048342-A1 | ANTIBACTERIAL COMPOUNDS | Janssen Sciences Ireland Unlimited Company (IE) | 2021-03-18 | — | — | WO | disclosed |
| US-20200316054-A1 | DOSAGES OF IMMUNOCONJUGATES OF ANTIBODIES AND SN-38 FOR IMPROVED EFFICACY AND DECREASED TOXICITY | IMMUNOMEDICS, INC. | 2020-10-08 | — | — | US | disclosed |
| US-10561738-B2 | Immunoconjugates with an intracellularly-cleavable linkage | IMMUNOMEDICS, INC. (US) | 2020-02-18 | — | — | US | disclosed |
| US-20170239368-A1 | Immunoconjugates with an Intracellularly-Cleavable Linkage | IMMUNOMEDICS, INC. | 2017-08-24 | — | — | US | disclosed |
| WO-2016020200-A1 | NITROGEN-CONTAINING COMPOUNDS SUITABLE FOR USE IN THE PRODUCTION OF POLYURETHANES | EVONIK DEGUSSA GMBH (DE) | 2016-02-11 | — | — | WO | disclosed |
| US-8138330-B2 | Solid phase synthesis via deblocking immobilized nucleoside, then coupling acyl protected nucleoside phosphoramidite | SIGMA-ALDRICH CO. LLC (US) | 2012-03-20 | — | — | US | disclosed |
| US-20080064867-A1 | PROCESS FOR THE SYNTHESIS OF OLIGONUCLEOTIDES | SIGMA ALDRICH COMPANY (US) | 2008-03-13 | — | — | US | disclosed |
| EP-0619492-B1 | Determination of an analyte in a liquid sample | BOEHRINGER MANNHEIM GMBH (DE) | 1998-07-01 | — | — | EP | disclosed |
| EP-0619492-A1 | Determination of an analyte in a liquid sample | Roche Diagnostics GmbH (DE) | 1994-10-12 | — | — | EP | disclosed |
| EP-0132678-A1 | Copolymers of methyl esters of N-vinyl-carbamic acid | BAYER AG (DE) | 1985-02-13 | — | — | EP | disclosed |