Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 1/20 | 0.53 |
| ▸ | EPHX2 | P34913 | 5/20 | 0.48 |
| ▸ | PPARG | P37231 | 5/20 | 0.48 |
| ▸ | CTSS | P25774 | 4/20 | 0.48 |
| ▸ | CTSK | P43235 | 4/20 | 0.48 |
| ▸ | CTSL | P07711 | 1/20 | 0.48 |
| ▸ | CTSB | P07858 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | REN | P00797 | 1/20 | 0.44 |
| ▸ | ACE | P12821 | 1/20 | 0.44 |
| ▸ | IDO1 | P14902 | 1/20 | 0.44 |
| ▸ | PTPRB | P23467 | 1/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1185840 | 0.95 | SYK (0.57) | SYKEPHX2PPARGCTSSCTSK | |
| SCHEMBL2799915 | 0.86 | EPHX2 (0.59) | SYKEPHX2PPARG | |
| SCHEMBL13816316 | 0.85 | SYK (0.56) | SYKCTSSCTSKCTSLCTSB | |
| SCHEMBL4769213 | 0.85 | SYK (0.54) | SYKEPHX2PPARGCTSSCTSK | |
| SCHEMBL21974545 | 0.84 | SYK (0.56) | SYKPPARGCTSSCTSKCTSL | |
| SCHEMBL17592938 | 0.84 | CTSS (0.49) | SYKEPHX2PPARGCTSSCTSK | |
| SCHEMBL23699326 | 0.82 | EPHX2 (0.56) | EPHX2PPARGATMMMP8 | |
| SCHEMBL825959 | 0.82 | ATM (0.55) | SYKCTSSCTSKCTSLCTSB | |
| SCHEMBL1186455 | 0.82 | ATM (0.55) | SYKCTSSCTSKCTSLCTSB | |
| SCHEMBL3825012 | 0.82 | ATM (0.55) | SYKCTSSCTSKCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0866705-A4 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5852045-A | Fibrinogen receptor antagonists | MERCK & CO., INC. (US) | 1998-12-22 | — | — | US | disclosed |
| EP-0866705-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-09-30 | — | — | EP | disclosed |
| WO-1997014417-A1 | FIBRINOGEN RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1997-04-24 | — | — | WO | disclosed |