Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | KLK5 | Q9Y337 | 1/20 | 0.55 |
| ▸ | REN | P00797 | 1/20 | 0.55 |
| ▸ | CMA1 | P23946 | 12/20 | 0.54 |
| ▸ | F2 | P00734 | 2/20 | 0.54 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.53 |
| ▸ | ACE | P12821 | 1/20 | 0.53 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.51 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.51 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.51 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.51 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.51 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7348799 | 1.00 | MAPK1 (0.55) | MAPK1KLK5RENCMA1F2 | |
| SCHEMBL7352303 | 0.94 | F2 (0.59) | KLK5RENCMA1F2PRSS1 | |
| SCHEMBL7352316 | 0.94 | F2 (0.59) | KLK5RENCMA1F2PRSS1 | |
| SCHEMBL7354569 | 0.91 | KLK5 (0.59) | KLK5RENCMA1F2PRSS1 | |
| SCHEMBL7354560 | 0.91 | KLK5 (0.59) | KLK5RENCMA1F2PRSS1 | |
| SCHEMBL7348910 | 0.89 | CMA1 (0.65) | KLK5CMA1F2 | |
| SCHEMBL7348917 | 0.89 | CMA1 (0.65) | KLK5CMA1F2 | |
| SCHEMBL7356585 | 0.86 | CMA1 (0.56) | MAPK1RENCMA1F2PRSS1 | |
| SCHEMBL7354216 | 0.86 | KLK5 (0.51) | KLK5RENCMA1F2PRSS1 | |
| SCHEMBL7354222 | 0.86 | KLK5 (0.51) | KLK5RENCMA1F2PRSS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1993025574-A1 | INHIBITORS OF ANGIOTENSIN I CHYMASE(S) INCLUDING HUMAN HEART CHYMASE | PFIZER INC. (US) | 1993-12-23 | — | — | WO | disclosed |