Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 6/20 | 0.65 |
| ▸ | APP | P05067 | 5/20 | 0.57 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.50 |
| ▸ | AR | P10275 | 1/20 | 0.50 |
| ▸ | CA12 | O43570 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 1/20 | 0.50 |
| ▸ | CA3 | P07451 | 1/20 | 0.50 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.50 |
| ▸ | CA4 | P22748 | 1/20 | 0.50 |
| ▸ | CA6 | P23280 | 1/20 | 0.50 |
| ▸ | CA5A | P35218 | 1/20 | 0.50 |
| ▸ | CA7 | P43166 | 1/20 | 0.50 |
| ▸ | CA9 | Q16790 | 1/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL734502 | 1.00 | MAOB (0.65) | MAOBAPPPTPN1NPC1RAB9A | |
| SCHEMBL29873464 | 0.90 | APP (0.64) | MAOBAPPPTPN1NPC1RAB9A | |
| SCHEMBL6748778 | 0.90 | APP (0.64) | MAOBAPPPTPN1NPC1RAB9A | |
| SCHEMBL729457 | 0.89 | APP (0.73) | MAOBAPPNPC1RAB9AKDM4E | |
| SCHEMBL735788 | 0.89 | APP (0.73) | MAOBAPPNPC1RAB9AKDM4E | |
| SCHEMBL7117562 | 0.85 | MAOB (0.66) | MAOBAPPPTPN1NPC1RAB9A | |
| SCHEMBL20473173 | 0.84 | MAOB (0.58) | MAOBAPPPTPN1NPC1RAB9A | |
| SCHEMBL10047398 | 0.84 | APP (0.57) | MAOBAPPPTPN1NPC1RAB9A | |
| SCHEMBL6822627 | 0.83 | NPC1 (0.66) | APPPTPN1NPC1RAB9AKDM4E | |
| SCHEMBL3922788 | 0.83 | APP (0.64) | MAOBAPPNPC1RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120189545-A1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS | UNIVERSITY OF PITTSBURGH -- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2012-07-26 | — | — | US | disclosed |
| US-20120148494-A1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS | UNIVERSITY OF PITTSBURGH -- OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2012-06-14 | — | — | US | disclosed |
| US-8138360-B2 | substrates for amyloidogenic proteins, for example, A beta 1-42, an amyloid protein, brain deposits of which are associated with Alzheimer's disease | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2012-03-20 | — | — | US | disclosed |
| US-8138360-B2 | substrates for amyloidogenic proteins, for example, A beta 1-42, an amyloid protein, brain deposits of which are associated with Alzheimer's disease | University of Pittsburgh—of the Commonwealth System of Higher Education (US) | 2012-03-20 | — | — | US | disclosed |
| EP-1945622-B1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGINGAGENTS FOR AMYLOIDOGENIC PROTEINS | UNIV PITTSBURGH (US) | 2011-12-28 | — | — | EP | disclosed |
| US-20080274058-A1 | Isotopically-Labeled Benzofuran Compounds as Imaging Agents for Amyloidogenic Proteins | UNIVERSITY OF PITTSBURGH- OF COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2008-11-06 | — | — | US | disclosed |
| US-20080274058-A1 | Isotopically-Labeled Benzofuran Compounds as Imaging Agents for Amyloidogenic Proteins | UNIVERSITY OF PITTSBURGH- OF COMMONWEALTH SYSTEM OF HIGHER EDUCATION | 2008-11-06 | — | — | US | disclosed |
| WO-2007047204-A1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGINGAGENTS FORAMYLOIDOGENIC PROTEINS | UNIVERSITY OF PITTSBURGH (US) | 2007-04-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120148494-A1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS | BACE1, APP, BACE2 | MAOB 1812/4885APP 2/4885PTPN1 4869/4885 |
| US-20080274058-A1 | Isotopically-Labeled Benzofuran Compounds as Imaging Agents for Amyloidogenic Proteins | BACE1, APP, BACE2 | MAOB 1693/4885APP 2/4885PTPN1 4859/4885 |
| US-20120189545-A1 | ISOTOPICALLY-LABELED BENZOFURAN COMPOUNDS AS IMAGING AGENTS FOR AMYLOIDOGENIC PROTEINS | BACE1, APP, BACE2 | MAOB 1693/4885APP 2/4885PTPN1 4859/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.