Sugi Predict

Sugi Predict / Compounds / SCHEMBL6748778

SCHEMBL6748778

SCHEMBL6748778

COc1ccc(-c2cc3ccc(OC)cc3o2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ APP P05067 5/20 0.64
▸ MAOB P27338 5/20 0.63
▸ ALDH1A1 P00352 5/20 0.59
▸ KDM4E B2RXH2 4/20 0.59
▸ HPGD P15428 4/20 0.59
▸ HSD17B10 Q99714 3/20 0.59
▸ MAPT P10636 3/20 0.59
▸ SMN1; SMN2 Q16637 3/20 0.59
▸ NPC1 O15118 2/20 0.59
▸ LMNA P02545 2/20 0.59
▸ TP53 P04637 2/20 0.59
▸ CYP3A4 P08684 2/20 0.59
▸ THRB P10828 2/20 0.59
▸ RAB9A P51151 2/20 0.59
▸ NFKB1 P19838 1/20 0.59
▸ NFKB2 Q00653 1/20 0.59
▸ RELA Q04206 1/20 0.59
▸ RXFP1 Q9HBX9 1/20 0.59
▸ EGFR P00533 1/20 0.58
▸ PTPN1 P18031 2/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29873464 1.00 APP (0.64) APPMAOBALDH1A1KDM4EHPGD
SCHEMBL7117562 0.91 MAOB (0.66) APPMAOBALDH1A1KDM4EHPGD
SCHEMBL20473173 0.90 MAOB (0.58) APPMAOBALDH1A1KDM4EHPGD
SCHEMBL21860492 0.90 KCNA5 (0.61) APPMAOBALDH1A1KDM4EHPGD
SCHEMBL10047398 0.90 APP (0.57) APPMAOBALDH1A1KDM4EHPGD
SCHEMBL734502 0.90 MAOB (0.65) APPMAOBALDH1A1KDM4EHPGD
SCHEMBL734884 0.90 MAOB (0.65) APPMAOBALDH1A1KDM4EHPGD
SCHEMBL6822627 0.89 NPC1 (0.66) APPALDH1A1KDM4EHPGDHSD17B10
SCHEMBL11733704 0.89 KCNA5 (0.62) APPMAOBALDH1A1KDM4EHPGD
SCHEMBL14833013 0.87 APP (0.82) APPMAOBALDH1A1KDM4EHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 39 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108690045-B Diarylethene compounds and uses thereof 首诺加拿大公司 2022-08-30 — — CN disclosed
US-11124524-B2 Diarylethene compounds and uses thereof SOLUTIA CANADA INC. (US) 2021-09-21 — — US disclosed
US-11124524-B2 Diarylethene compounds and uses thereof SOLUTIA CANADA INC. (US) 2021-09-21 — — US disclosed
US-10556912-B2 Diarylethene compounds and uses thereof SWITCH MATERIALS, INC. (CA) 2020-02-11 — — US disclosed
US-10556912-B2 Diarylethene compounds and uses thereof SWITCH MATERIALS, INC. (CA) 2020-02-11 — — US disclosed
US-20190256526-A1 DIARYLETHENE COMPOUNDS AND USES THEREOF SWITCH MATERIALS, INC. (CA) 2019-08-22 — — US disclosed
US-20190256526-A1 DIARYLETHENE COMPOUNDS AND USES THEREOF SWITCH MATERIALS, INC. (CA) 2019-08-22 — — US disclosed
US-20180339995-A1 PHOTOCHROMIC AND ELECTROCHROMIC DIARYLCYCLOPENTENE DERIVATIVES AS OPTICAL FILTERS SWITCH MATERIALS, INC. (CA) 2018-11-29 — — US disclosed
EP-3385354-A1 DIARYLETHENE COMPOUNDS AND USES THEREOF Switch Materials, Inc. (CA) 2018-10-10 — — EP disclosed
US-10072023-B2 Diarylethene compounds and uses thereof SWITCH MATERIALS, INC. (CA) 2018-09-11 — — US disclosed
EP-0774966-B1 BENZOFURAN COMPOUNDS, COMPOSITIONS, AND METHODS LILLY CO ELI (US) 2003-11-05 — — EP disclosed
US-6407243-B1 POSTMEMOPAUSE DISEASES ELI LILLY AND COMPANY 2002-06-18 — — US disclosed
US-6350777-B2 METHOXY/ETHOXY SUBSTITUTED 3-AROYL-2-ARYLBENZO(B)THIOPHENES AND BENZO(B)THIOPHENE ANALOGUES; ANTITUMOR AGENTS; CYTOTOXICITY BAYLOR UNIVERSITY 2002-02-26 — — US disclosed
US-20010034454-A1 Description anti-mitotic agents which inhibit tubulin polymerization BYLOR UNIVERSITY AND ARIZONA DESEASE CONTROL RESEARCH COMMISSION 2001-10-25 — — US disclosed
US-6162930-A Anti-mitotic agents which inhibit tubulin polymerization BAYLOR UNIVERSITY (US) 2000-12-19 — — US disclosed
US-5747524-A BENZOTHIOPHENES AND BENZOFURANS ELI LILLY AND COMPANY (US) 1998-05-05 — — US disclosed
EP-0766559-A4 CANNABINOID RECEPTOR ANTAGONISTS LILLY CO ELI (US) 1997-08-06 — — EP disclosed
EP-0766559-A1 CANNABINOID RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 1997-04-09 — — EP disclosed
US-5596106-A ARYL-BENZO(B)THIOPHENE OR BENZO(B)FURAN COMPOUNDS ELI LILLY AND COMPANY (US) 1997-01-21 — — US disclosed
WO-1996002248-A1 CANNABINOID RECEPTOR ANTAGONISTS ELI LILLY AND COMPANY (US) 1996-02-01 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190256526-A1 DIARYLETHENE COMPOUNDS AND USES THEREOF KCNH2, KCNH3, SCN2B APP 3371/4885MAOB 1025/4885ALDH1A1 1014/4885
US-10556912-B2 Diarylethene compounds and uses thereof KCNH2, KCNH3, SCN2B APP 3371/4885MAOB 1025/4885ALDH1A1 1014/4885
US-20010034454-A1 Description anti-mitotic agents which inhibit tubulin polymerization TUBB, TUBB1, TUBB3 APP 4153/4885MAOB 1299/4885ALDH1A1 2348/4885
US-11124524-B2 Diarylethene compounds and uses thereof KCNH2, KCNH3, SCN2B APP 3371/4885MAOB 1025/4885ALDH1A1 1014/4885
US-20180339995-A1 PHOTOCHROMIC AND ELECTROCHROMIC DIARYLCYCLOPENTENE DERIVATIVES AS OPTICAL FILTERS HCN2, KCNH2, KCNH3 APP 3543/4885MAOB 656/4885ALDH1A1 939/4885
US-10072023-B2 Diarylethene compounds and uses thereof KCNH2, KCNH3, SCN2B APP 3371/4885MAOB 1025/4885ALDH1A1 1014/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.