SCHEMBL7349488

SCHEMBL7349488

COC(=O)C1=C(C)NC(C)=C(C(=O)OCCN2Cc3ccccc3C2)C1c1cc([N+](=O)[O-])ccc1Cl

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 7/20 0.52
CYP1A2 P05177 6/20 0.52
CYP3A4 P08684 6/20 0.52
CYP2C9 P11712 6/20 0.52
CYP2C19 P33261 6/20 0.52
ADRA1A P35348 5/20 0.52
TDP1 Q9NUW8 5/20 0.52
CYP2D6 P10635 5/20 0.52
MEN1 O00255 5/20 0.52
KMT2A Q03164 5/20 0.52
ADRA2A P08913 4/20 0.52
ADRA2B P18089 3/20 0.52
ADRA2C P18825 3/20 0.52
ADRA1D P25100 3/20 0.52
ADRA1B P35368 3/20 0.52
ABCB1 P08183 3/20 0.52
ADORA3 P0DMS8 3/20 0.52
CHRM2 P08172 2/20 0.52
HTR1A P08908 2/20 0.52
DRD1 P21728 2/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7349519 0.86 ADORA3 (0.57) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL7343603 0.85 MAPT (0.70) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL7347116 0.85 HSD17B10 (0.56) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL7343697 0.85 ADORA3 (0.54) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL7351367 0.84 ADORA3 (0.69) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL7349491 0.84 HIF1A (0.59) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL7349496 0.83 CYP1A2 (0.48) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL11829575 0.83 ADORA3 (0.69) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL7343960 0.82 ADORA3 (0.50) MAPTCYP1A2CYP3A4CYP2C9CYP2C19
SCHEMBL7349484 0.82 CYP1A2 (0.48) MAPTCYP1A2CYP3A4CYP2C9CYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4652573-A HYPOTENSIVE AGENTS NELSON RESEARCH & DEVELOPMENT CO. (US) 1987-03-24 US claimed
US-4833150-A HYPOTENSIVES, ANTIARRHYTHMIA AGENTS NELSON RESEARCH & DEVELOPMENT CO. (US) 1989-05-23 US disclosed
US-4652573-A HYPOTENSIVE AGENTS NELSON RESEARCH & DEVELOPMENT CO. (US) 1987-03-24 US disclosed
EP-0194685-A1 1,4-Dihydropyridines Whitby Research Incorporated (US) 1986-09-17 EP disclosed