Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.60 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.60 |
| ▸ | PLK1 | P53350 | 1/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | BCAT1 | P54687 | 1/20 | 0.47 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7349608 | 1.00 | TAS1R3 (0.60) | TAS1R3TAS1R1PLK1HDAC1HDAC2 | |
| SCHEMBL7340288 | 0.92 | TAS1R3 (0.59) | TAS1R3TAS1R1PLK1HDAC1HDAC2 | |
| SCHEMBL3492806 | 0.79 | PLK1 (0.72) | TAS1R3TAS1R1PLK1HDAC1HDAC2 | |
| SCHEMBL31419202 | 0.79 | PLK1 (0.72) | TAS1R3TAS1R1PLK1HDAC1HDAC2 | |
| SCHEMBL4165636 | 0.77 | TAS1R3 (0.79) | TAS1R3TAS1R1PLK1HDAC1HDAC2 | |
| SCHEMBL9749106 | 0.76 | PLK1 (0.73) | TAS1R3TAS1R1PLK1HDAC1HDAC2 | |
| SCHEMBL7330575 | 0.76 | MGAM (0.52) | BCAT1CCR1 | |
| SCHEMBL4203545 | 0.75 | TAS1R3 (1.00) | TAS1R3TAS1R1PLK1ALOX15HTT | |
| SCHEMBL4203543 | 0.75 | TAS1R3 (1.00) | TAS1R3TAS1R1PLK1ALOX15HTT | |
| SCHEMBL703553 | 0.75 | PLK1 (0.63) | TAS1R3TAS1R1PLK1HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1005448-A2 | NOVEL INHIBITORS OF AGGRECANASE AND MATRIX METALLOPROTEINASES FOR THE TREATMENT OF ARTHRITIS | Du Pont Pharmaceuticals Company (US) | 2000-06-07 | — | — | EP | disclosed |
| WO-1999009000-A2 | NOVEL INHIBITORS OF AGGRECANASE AND MATRIX METALLOPROTEINASES FOR THE TREATMENT OF ARTHRITIS | DU PONT PHARMACEUTICALS COMPANY (US) | 1999-02-25 | — | — | WO | disclosed |