Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FDPS | P14324 | 1/20 | 0.67 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.62 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.62 |
| ▸ | NPC1 | O15118 | 2/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 11/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 11/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.59 |
| ▸ | HTT | P42858 | 3/20 | 0.59 |
| ▸ | LMNA | P02545 | 3/20 | 0.59 |
| ▸ | HPGD | P15428 | 6/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | TTR | P02766 | 1/20 | 0.55 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9713042 | 0.99 | FDPS (0.68) | FDPSCYP2C9NPSR1NPC1RAB9A | |
| SCHEMBL6942920 | 0.95 | MAPT (0.59) | FDPSCYP2C9NPSR1NPC1RAB9A | |
| SCHEMBL6228384 | 0.95 | MAPT (0.59) | FDPSCYP2C9NPSR1NPC1RAB9A | |
| SCHEMBL7545268 | 0.93 | MAPT (0.60) | FDPSCYP2C9NPSR1NPC1RAB9A | |
| SCHEMBL6949716 | 0.91 | MAPT (0.55) | FDPSCYP2C9NPSR1NPC1RAB9A | |
| SCHEMBL6950497 | 0.91 | MAPT (0.55) | FDPSCYP2C9NPSR1NPC1RAB9A | |
| SCHEMBL9078005 | 0.91 | FDPS (0.72) | FDPSCYP2C9NPSR1NPC1RAB9A | |
| SCHEMBL31331562 | 0.91 | FDPS (0.72) | FDPSCYP2C9NPSR1NPC1RAB9A | |
| SCHEMBL30467197 | 0.90 | FDPS (0.54) | FDPSCYP2C9NPSR1NPC1RAB9A | |
| SCHEMBL21427194 | 0.90 | FDPS (0.54) | FDPSCYP2C9NPSR1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6297257-B1 | Benzazine derivatives phosphodiesterase 4 inhibitors | ZAMBON GROUP S.P.A. (IT) | 2001-10-02 | — | — | US | disclosed |
| EP-1060173-A2 | BENZAZINE DERIVATIVES PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.p.A. (IT) | 2000-12-20 | — | — | EP | disclosed |
| WO-1999032449-A2 | BENZAZINE DERIVATIVES AS PHOSPHODIESTERASE 4 INHIBITORS | ZAMBON GROUP S.P.A. (IT) | 1999-07-01 | — | — | WO | disclosed |