Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 6/20 | 0.68 |
| ▸ | MME | P08473 | 5/20 | 0.68 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.56 |
| ▸ | OPRM1 | P35372 | 4/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7449059 | 1.00 | ACE (0.68) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7349691 | 1.00 | ACE (0.68) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7349703 | 1.00 | ACE (0.68) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7445121 | 0.88 | ACE (0.63) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7445113 | 0.88 | ACE (0.63) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7344775 | 0.86 | ACE (0.79) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7344771 | 0.86 | ACE (0.79) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7444221 | 0.86 | ACE (0.79) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7344781 | 0.86 | ACE (0.79) | ACEMMEHRH4OPRM1OPRD1 | |
| SCHEMBL7443809 | 0.85 | ACE (0.71) | ACEMMEHRH4OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0599444-B1 | Dual action inhibitors | SQUIBB & SONS INC (US) | 1998-01-28 | — | — | EP | disclosed |
| EP-0783002-A2 | Dual action inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1997-07-09 | — | — | EP | disclosed |
| US-5646276-A | ANGIOTENSIN CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE INHIBITORS; CARDIOVASCULAR DISORDERS | BRISTOL-MYERS SQUIBB CO. (US) | 1997-07-08 | — | — | US | disclosed |
| US-5552397-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1996-09-03 | — | — | US | disclosed |
| WO-1994026719-A1 | MERCAPTO-AMIDE DERIVATIVES USEFUL AS NEUTRAL ENDOPEPTIDASE AND ACE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-11-24 | — | — | WO | disclosed |
| EP-0599444-A1 | Dual action inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1994-06-01 | — | — | EP | disclosed |